Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637313 | 0.89 | RORC (0.52) | RORCPOLBTP53MAPTMEN1 | |
| SCHEMBL8641097 | 0.87 | RORC (0.49) | RORCPOLBATMTP53MAPT | |
| SCHEMBL9569701 | 0.87 | RORC (0.45) | RORCTP53GPR139MAPTADORA1 | |
| SCHEMBL9569710 | 0.85 | RORC (0.46) | RORCPOLBTP53MAPTKMT2A | |
| SCHEMBL10916806 | 0.84 | RORC (0.45) | RORCPOLBATMSCN9AMAPT | |
| SCHEMBL8830007 | 0.83 | RORC (0.44) | RORCPOLBSCN9ATP53MAPT | |
| SCHEMBL30626350 | 0.80 | SCN9A (0.41) | POLBATMSCN9AMAPTPTGDR2 | |
| SCHEMBL26074932 | 0.80 | SCN9A (0.41) | POLBATMSCN9AMAPTPTGDR2 | |
| SCHEMBL8639493 | 0.80 | CCR2 (0.45) | RORCTP53MAPTMEN1KMT2A | |
| SCHEMBL8638653 | 0.77 | KMT2A (0.43) | RORCPOLBTP53MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519140-B1 | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acids, esters and salts thereof, and intermediates used in this method | HYBRINOVA (FR) | 1998-07-29 | — | — | EP | disclosed |
| US-5696055-A | USED IN INDUCING MALE STERILITY OR PRODUCING HYBRID SEEDS IN A GRAMINEOUS PLANT | HYBRINOVA S.A. (FR) | 1997-12-09 | — | — | US | disclosed |
| EP-0363236-B1 | Pollen suppressant comprising a 5-oxy- or amino-substituted cinnoline | HYBRINOVA (FR) | 1994-12-07 | — | — | EP | disclosed |
| US-5332716-A | Pollen suppressant comprising a 5-oxy- or amino-substituted cinnoline | E.I. DU PONT DE NEMOURS AND COMPANY | 1994-07-26 | — | — | US | disclosed |
| US-5304672-A | Intermediates for pollen suppressants | ORSAN (FR) | 1994-04-19 | — | — | US | disclosed |
| US-5183891-A | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acid, esters and salts thereof, and intermediates used in their preparation | ORSAN (FR) | 1993-02-02 | — | — | US | disclosed |
| EP-0519140-A1 | Method for the preparation of substituted 1,4-dihydro-4-oxo-cinnoline-3-carboxylic acid, esters and salts thereof, and intermediates used in their preparation | HYBRINOVA (FR) | 1992-12-23 | — | — | EP | disclosed |
| US-5129939-A | Antifertility agents | ORSAN (FR) | 1992-07-14 | — | — | US | disclosed |
| EP-0363236-A1 | Pollen suppressant comprising a 5-oxy- or amino-substituted cinnoline | HYBRINOVA (FR) | 1990-04-11 | — | — | EP | disclosed |