Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 7/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639348 | 0.91 | KDM4E (0.49) | ACSS2GRIN1GRIN2BKDM4EMAPT | |
| SCHEMBL8641198 | 0.85 | LMNA (0.53) | KDM4EGAAMAPTPKMTDP1 | |
| SCHEMBL8640797 | 0.73 | RAB9A (0.60) | ACSS2KDM4EGAAMAPTPKM | |
| SCHEMBL8732491 | 0.69 | MAOA (0.68) | GRIN1GRIN2BGAAMAPTTDP1 | |
| SCHEMBL17487719 | 0.68 | NPC1 (0.59) | GAAMAPTPKMALDH1A1POLB | |
| SCHEMBL615476 | 0.68 | TNF (0.68) | ACSS2KDM4EBRD4ALDH1A1TP53 | |
| SCHEMBL615475 | 0.68 | KDM4E (0.73) | ACSS2KDM4EGAAMAPTTDP1 | |
| SCHEMBL17487335 | 0.67 | KDM4E (0.46) | GRIN1GRIN2BKDM4EALDH1A1HTT | |
| SCHEMBL17263072 | 0.66 | ACSS2 (1.00) | ACSS2 | |
| SCHEMBL7453184 | 0.66 | GRIN1 (1.00) | GRIN1GRIN2BKDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |