Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637102 | 0.91 | ACSS2 (0.49) | KDM4EALDH1A1HTTPOLBGRIN1 | |
| SCHEMBL8641198 | 0.85 | LMNA (0.53) | KDM4EALDH1A1HTTCNR2TDP1 | |
| SCHEMBL8640797 | 0.73 | RAB9A (0.60) | KDM4EPOLBLMNATP53MEN1 | |
| SCHEMBL5228756 | 0.72 | LMNA (0.55) | KDM4ERAD52ALDH1A1HTTLMNA | |
| SCHEMBL8732491 | 0.69 | MAOA (0.68) | ALDH1A1GRIN1GRIN2BTDP1MEN1 | |
| SCHEMBL6827567 | 0.68 | KDM4E (0.66) | KDM4EALDH1A1CNR2TDP1HDAC1 | |
| SCHEMBL2123643 | 0.68 | KDM4E (0.48) | KDM4ERAD52ALDH1A1HTTCNR2 | |
| SCHEMBL617824 | 0.68 | TNF (0.68) | KDM4ERAD52ALDH1A1HTTPOLB | |
| SCHEMBL616998 | 0.68 | KDM4E (0.97) | KDM4ERAD52ALDH1A1HTTTDP1 | |
| SCHEMBL4976587 | 0.67 | KDM4E (0.63) | KDM4ERAD52ALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |