Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641198 | 0.87 | LMNA (0.53) | RAB9AMAPTNPC1CYP1A2CYP3A4 | |
| SCHEMBL13071550 | 0.76 | CYP1A2 (0.59) | RAB9AMAPTNPC1CYP1A2CYP3A4 | |
| SCHEMBL8637102 | 0.73 | ACSS2 (0.49) | MAPTTP53KDM4EACSS2LMNA | |
| SCHEMBL8639348 | 0.73 | KDM4E (0.49) | MAPTKMT2AMEN1TP53KDM4E | |
| SCHEMBL21803205 | 0.73 | ACSS2 (0.66) | RAB9AMAPTNPC1CYP1A2CYP3A4 | |
| SCHEMBL16432406 | 0.73 | PTGER4 (0.45) | RAB9ANPC1KMT2AMEN1ACSS2 | |
| SCHEMBL12162198 | 0.72 | MAPT (0.43) | RAB9AMAPTNPC1CYP1A2CYP2C19 | |
| SCHEMBL9124521 | 0.72 | AGTR1 (0.65) | MAPTTP53SMN1; SMN2 | |
| SCHEMBL20715463 | 0.71 | RAB9A (0.76) | RAB9AMAPTNPC1CYP1A2CYP3A4 | |
| SCHEMBL7260311 | 0.71 | MAPT (0.68) | RAB9AMAPTNPC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |