Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639322 | 0.74 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2HRH1LTA4HF10 | |
| SCHEMBL8635989 | 0.73 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2HRH1LTA4HITGB3 | |
| SCHEMBL8640865 | 0.71 | HRH1 (0.50) | ALDH1A1SMN1; SMN2HRH1LTA4H | |
| SCHEMBL13033926 | 0.71 | LMNA (0.56) | ALDH1A1 | |
| SCHEMBL2633261 | 0.70 | LMNA (0.68) | ALDH1A1ITGB3ITGA2B | |
| SCHEMBL8644228 | 0.69 | LTA4H (0.52) | ALDH1A1SMN1; SMN2HRH1LTA4HITGB3 | |
| SCHEMBL1980094 | 0.68 | GHSR (0.45) | ALDH1A1ITGB3ITGA2B | |
| SCHEMBL8637335 | 0.68 | LTA4H (0.56) | ALDH1A1HRH1LTA4HITGB3ITGA2B | |
| SCHEMBL11390159 | 0.68 | RECQL (0.75) | ALDH1A1SMN1; SMN2ACACB | |
| SCHEMBL8641254 | 0.67 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |