Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658972 | 0.91 | SMN1; SMN2 (0.39) | LMNAKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL8643511 | 0.89 | LMNA (0.35) | LMNAKDM4EACHEMAOBALDH1A1 | |
| SCHEMBL8637479 | 0.85 | ACHE (0.38) | ACHE | |
| SCHEMBL9170026 | 0.84 | ROCK2 (0.40) | KDM4EACHEMAOBALDH1A1SMN1; SMN2 | |
| SCHEMBL9004593 | 0.83 | LMNA (0.46) | LMNAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL8639190 | 0.81 | LMNA (0.35) | LMNAKDM4EALDH1A1GLAHPGD | |
| SCHEMBL8638777 | 0.80 | MAOA (0.38) | MAOBMEN1KMT2A | |
| SCHEMBL9167754 | 0.80 | ALDH1A1 (0.36) | LMNAKDM4EACHEMAOBALDH1A1 | |
| SCHEMBL8638609 | 0.78 | CYP1A2 (0.40) | KDM4EACHEALDH1A1HPGDHTT | |
| SCHEMBL9166368 | 0.78 | ACHE (0.32) | LMNAACHEMAOBALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | claimed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |