Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639136 | 0.85 | SMN1; SMN2 (0.42) | MAPTALDH1A1CD274CRHBPCRHR2 | |
| SCHEMBL8637439 | 0.77 | LTA4H (0.50) | LMNAALDH1A1CD274SMN1; SMN2SIGMAR1 | |
| SCHEMBL8637725 | 0.76 | CRHBP (0.38) | MEN1MAPTKMT2AALDH1A1CRHBP | |
| SCHEMBL8639947 | 0.76 | LTA4H (0.51) | SCN1ASCN2ASCN3ALMNASIGMAR1 | |
| SCHEMBL8638274 | 0.74 | LTA4H (0.39) | KDM4ELMNA | |
| SCHEMBL8637445 | 0.73 | HRH1 (0.46) | HRH1SIGMAR1 | |
| SCHEMBL7246918 | 0.72 | CARM1 (0.40) | SMN1; SMN2 | |
| SCHEMBL8637805 | 0.72 | HRH3 (0.47) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL8641764 | 0.71 | HRH3 (0.50) | SIGMAR1 | |
| SCHEMBL3134730 | 0.71 | ALDH1A1 (0.40) | KDM4ELMNAMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |