Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639136 | 0.87 | SMN1; SMN2 (0.42) | LTA4HPDCD1CD274ALDH1A1SMN1; SMN2 | |
| SCHEMBL8638274 | 0.86 | LTA4H (0.39) | LTA4HLMNA | |
| SCHEMBL8637775 | 0.79 | MAOA (0.44) | LTA4HSIGMAR1DRD4TMEM97ALDH1A1 | |
| SCHEMBL8639947 | 0.78 | LTA4H (0.51) | LTA4HSIGMAR1LMNA | |
| SCHEMBL8637445 | 0.78 | HRH1 (0.46) | LTA4HSIGMAR1 | |
| SCHEMBL8638836 | 0.77 | KDM4E (0.38) | SIGMAR1LMNACD274ALDH1A1SMN1; SMN2 | |
| SCHEMBL8640950 | 0.75 | SCN3A (0.43) | LTA4HLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8644129 | 0.75 | LMNA (0.41) | LTA4HLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8638269 | 0.74 | LTA4H (0.50) | LTA4HSIGMAR1 | |
| SCHEMBL8641109 | 0.74 | LTA4H (0.52) | LTA4HSIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |