Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9041264 | 0.97 | SIGMAR1 (0.50) | SIGMAR1DRD4DRD2KCNH2 | |
| SCHEMBL7811838 | 0.91 | HTR2C (0.48) | KCNH2 | |
| SCHEMBL7805201 | 0.85 | HTR2C (0.43) | SIGMAR1DRD4DRD2 | |
| SCHEMBL7805133 | 0.78 | DRD2 (0.55) | SIGMAR1DRD2 | |
| SCHEMBL9166656 | 0.77 | SIGMAR1 (0.80) | SIGMAR1DRD4DRD2 | |
| SCHEMBL9014693 | 0.76 | SIGMAR1 (0.55) | SIGMAR1DRD4DRD2 | |
| SCHEMBL7822917 | 0.75 | HTR2C (0.41) | — | |
| SCHEMBL7805210 | 0.75 | ADRA1D (0.45) | SIGMAR1KCNH2 | |
| SCHEMBL7811843 | 0.74 | ADRA1B (0.41) | SIGMAR1DRD4DRD2 | |
| SCHEMBL7397389 | 0.74 | DRD4 (0.66) | SIGMAR1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |
| EP-0745598-A1 | Piperazine, piperidine and 1,2,5,6-tetrahydropyridine derivatives, proces for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |