Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639947 | 0.86 | LTA4H (0.51) | SCN3ALMNAFAAHLTA4H | |
| SCHEMBL8637785 | 0.86 | SCN3A (0.53) | SCN3ASPHK2SPHK1SMN1; SMN2 | |
| SCHEMBL8637805 | 0.85 | HRH3 (0.47) | LMNARECQLSMN1; SMN2 | |
| SCHEMBL8644129 | 0.84 | LMNA (0.41) | LMNASPHK2SPHK1ALDH1A1LTA4H | |
| SCHEMBL8637445 | 0.81 | HRH1 (0.46) | LTA4H | |
| SCHEMBL8637775 | 0.80 | MAOA (0.44) | SPHK2SPHK1ALDH1A1LTA4HSMN1; SMN2 | |
| SCHEMBL8641764 | 0.80 | HRH3 (0.50) | SPHK2SPHK1LTA4H | |
| SCHEMBL7246918 | 0.79 | CARM1 (0.40) | SMN1; SMN2 | |
| SCHEMBL8639270 | 0.79 | LTA4H (0.44) | SPHK2SPHK1LTA4H | |
| SCHEMBL8641796 | 0.77 | FFAR1 (0.50) | SCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723492-A | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1998-03-03 | — | — | US | disclosed |
| US-5719306-A | ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |