SCHEMBL8647451

SCHEMBL8647451

CC[Si](CC)(CC)Oc1cccc(S(OS(=O)(=O)c2ccc(F)cc2)(c2ccccc2)c2cccc(O[Si](CC)(CC)CC)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
HSD17B10 Q99714 1/20 0.38
FFAR1 O14842 2/20 0.35
NR3C1 P04150 1/20 0.35
F2 P00734 4/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
FFAR4 Q5NUL3 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TP53 P04637 1/20 0.34
MEN1 O00255 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ALDH1A1 P00352 1/20 0.33
PKM P14618 1/20 0.33
PGR P06401 1/20 0.32
CETP P11597 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8648343 0.90 KMT2A (0.41) KMT2ATSHRMAPK1HSD17B10FFAR1
SCHEMBL8649985 0.82 NR1H2 (0.33)
SCHEMBL8644649 0.80 FFAR1 (0.37) KMT2AFFAR1SMN1; SMN2FFAR4L3MBTL1
SCHEMBL2955282 0.78 KMT2A (0.49) KMT2ATSHRMAPK1HSD17B10FFAR1
SCHEMBL8651782 0.75 F2 (0.41) KMT2AMAPK1F2SMN1; SMN2L3MBTL1
SCHEMBL8651563 0.75 PKM (0.35) KMT2ATSHRFFAR1F2FFAR4
SCHEMBL8647447 0.74 TSHR (0.38) KMT2ATSHRMAPK1HSD17B10FFAR1
SCHEMBL8323445 0.74 PGR (0.34) HSD17B10SMN1; SMN2ALDH1A1PGR
SCHEMBL2958287 0.74 STAT3 (0.48) FFAR1SMN1; SMN2FFAR4L3MBTL1ALDH1A1
SCHEMBL3137415 0.74 KMT2A (0.46) KMT2AMAPK1SMN1; SMN2MEN1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5824824-A AROMATIC SULFONATE ANIONS AND DISSOLUTION CONTRAST IN EXPOSED AND NONEXPOSED AREAS, POSITIVE RESISTS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-10-20 US disclosed