Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859996 | 0.88 | LMNA (0.44) | LMNASMN1; SMN2SIGMAR1ACLYPOLB | |
| SCHEMBL6883563 | 0.85 | IDO1 (0.47) | LMNASMN1; SMN2 | |
| SCHEMBL31634968 | 0.85 | IDO1 (0.47) | LMNASMN1; SMN2 | |
| SCHEMBL8425207 | 0.81 | LMNA (0.44) | LMNASMN1; SMN2CA2 | |
| SCHEMBL9825869 | 0.79 | ACLY (0.43) | LMNASIGMAR1ACLYPOLBMALT1 | |
| SCHEMBL1866143 | 0.79 | CA12 (0.42) | CA2 | |
| SCHEMBL9692319 | 0.79 | LMNA (0.36) | LMNASMN1; SMN2POLBTP53 | |
| SCHEMBL7966432 | 0.78 | LMNA (0.61) | LMNASMN1; SMN2POLBMTNR1ACA2 | |
| SCHEMBL8649232 | 0.78 | LMNA (0.44) | LMNASMN1; SMN2POLB | |
| SCHEMBL25082430 | 0.76 | SIGMAR1 (0.47) | SIGMAR1ACLYMALT1HTR1AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112855-A | Nootropic Agents | CIBA-GEIGY CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0252005-B1 | HYDROGENATED 1-BENZOOXACYCLOALKYL-PYRIDINE CARBOXYLIC-ACID COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| US-4957928-A | NOOTROPIC AGENTS, COGNITION ACTIVATORS | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| EP-0252005-A1 | Hydrogenated 1-benzooxacycloalkyl-pyridine carboxylic-acid compounds | CIBA-GEIGY AG (CH) | 1988-01-07 | — | — | EP | disclosed |