Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259453 | 0.80 | ALDH1A1 (1.00) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL9680379 | 0.80 | KDM4E (0.46) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL9717697 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL609785 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL5151528 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL272835 | 0.77 | ALDH1A1 (0.67) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL10909304 | 0.77 | ALDH1A1 (0.43) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL7433052 | 0.77 | KDM1A (0.44) | ALDH1A1KDM4EENPP1MAPK1HPGD | |
| SCHEMBL18358125 | 0.77 | ALDH1A1 (0.43) | ALDH1A1KDM4EENPP1MAPK1PKM | |
| SCHEMBL5164814 | 0.76 | ALDH1A1 (0.65) | ALDH1A1KDM4EENPP1MAPK1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020976-B | Pyrimidotriazole-indole-containing compound and preparation method and application thereof | 郑州大学 | 2020-04-17 | — | — | CN | claimed |
| US-12630556-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors | DART NEUROSCIENCE LLC (US) | 2026-05-19 | — | — | US | disclosed |
| US-12577217-B2 | 15-PGDH inhibitor | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2026-03-17 | — | — | US | disclosed |
| US-20250092047-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS | DART NEUROSCIENCE LLC | 2025-03-20 | — | — | US | disclosed |
| CN-113226310-B | 15-PGDH inhibitors | 杏林制药株式会社 | 2024-03-19 | — | — | CN | disclosed |
| US-20230192698-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230082516-A1 | 15-PGDH INHIBITOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2023-03-16 | — | — | US | disclosed |
| CN-110092788-B | Substituted [1,2,4] triazolo [1,5-a ] pyrimidin-7-yl compounds as PDE2 inhibitors | 达特神经科学(开曼)有限公司 | 2022-02-25 | — | — | CN | disclosed |
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| US-11186582-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors | Dart Neuroscience, (Cayman) LTD. (KY) | 2021-11-30 | — | — | US | disclosed |
| EP-0302132-B1 | Process and device for the preparation of 5-methyl-7-diethyl amino-s-triazolo[1,5-a] pyrimidine | Deutsche Hydrierwerke GmbH Rodleben (DE) | 1991-04-03 | — | — | EP | disclosed |
| EP-0393574-A2 | Hexitol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |
| EP-0335319-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4851321-A | HYDRAZINE DERIVATIVE, HETEROCYCLIC CONTRAST ENHANCER | FUJI PHOTO FILM CO., LTD. (JP) | 1989-07-25 | — | — | US | disclosed |
| US-4826834-A | BACTERICIDES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-05-02 | — | — | US | disclosed |
| EP-0302132-A1 | Process and device for the preparation of 5-methyl-7-diethyl amino-s-triazolo[1,5-a] pyrimidine | Deutsche Hydrierwerke GmbH Rodleben (DE) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302132-A1 | Process and device for the preparation of 5-methyl-7-diethyl amino-s-triazolo[1,5-a] pyrimidine | Deutsche Hydrierwerke GmbH Rodleben (DE) | 1989-02-08 | — | — | EP | disclosed |
| EP-0267598-A2 | Superhigh contrast negative-type silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-05-18 | — | — | EP | disclosed |
| EP-0216385-A2 | Antibacterial compounds | Takeda Chemical Industries, Ltd. (JP) | 1987-04-01 | — | — | EP | disclosed |
| EP-0153229-A2 | 1-Dethia 2-thia-cephalosporanic acid derivatives, process and intermediates for their preparation, their use as therapeutic agents and the compositions containing them | ROUSSEL-UCLAF (FR) | 1985-08-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230082516-A1 | 15-PGDH INHIBITOR | UGDH, HPGD, GCDH | ALDH1A1 103/4885KDM4E 3228/4885ENPP1 793/4885 |
| US-12577217-B2 | 15-PGDH inhibitor | PTGDR, ADH1A, ADRA1A | ALDH1A1 23/4885KDM4E 4111/4885ENPP1 2242/4885 |
| US-11186582-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors | PDE12, PDE2A, TDP2 | ALDH1A1 1494/4885KDM4E 3050/4885ENPP1 1840/4885 |
| US-20250092047-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, TDP2 | ALDH1A1 1494/4885KDM4E 3050/4885ENPP1 1840/4885 |
| US-20230192698-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, TDP2 | ALDH1A1 1509/4885KDM4E 3043/4885ENPP1 1728/4885 |
| US-12630556-B2 | Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as PDE2 inhibitors | PDE1A, PDE12, PDE1B | ALDH1A1 1599/4885KDM4E 1923/4885ENPP1 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.