Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650374 | 0.85 | CA2 (0.41) | MTNR1AMTNR1B | |
| SCHEMBL23612316 | 0.79 | CYP2A6 (0.41) | MTNR1AMTNR1BKEAP1NFE2L2HTR5A | |
| SCHEMBL8788477 | 0.77 | MTNR1A (0.38) | MTNR1AMTNR1BKEAP1NFE2L2HTR1A | |
| SCHEMBL8653030 | 0.76 | CYP2A6 (0.61) | MTNR1AMTNR1BKEAP1NFE2L2HDAC10 | |
| SCHEMBL8648779 | 0.76 | MTNR1A (0.58) | MTNR1AMTNR1BKEAP1NFE2L2CYP2A6 | |
| SCHEMBL8788554 | 0.75 | PSMD10 (0.41) | MTNR1AMTNR1B | |
| SCHEMBL8255715 | 0.72 | CYP2A6 (0.42) | MTNR1AMTNR1BKEAP1NFE2L2HTR1A | |
| SCHEMBL14155053 | 0.72 | CA2 (0.49) | MTNR1AMTNR1BKEAP1NFE2L2CYP2A6 | |
| SCHEMBL79170 | 0.72 | CYP2A6 (0.69) | MTNR1AHDAC6CYP2A6 | |
| SCHEMBL27989610 | 0.71 | HTR7 (0.74) | HTR1AHTR1DHTR2CMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763444-A | CENTRAL NERVOUS SYSTEM AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0761666-A2 | Antidepressant 1-arylalkyl-4-(alkoxypyridinyl)- or 4-(alkoxypyrimidinyl)piperazine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |