SCHEMBL865249

SCHEMBL865249

Clc1cccc(Cl)c1COCc1c(Cl)cccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.52
TAAR1 Q96RJ0 2/20 0.48
AKR1B1 P15121 1/20 0.44
KMT2A Q03164 2/20 0.42
IDO1 P14902 2/20 0.41
KDM4E B2RXH2 2/20 0.41
POLB P06746 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2A6 P11509 1/20 0.41
DPP4 P27487 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40
HSD11B1 P28845 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18788868 0.87 TSHR (0.62) SMN1; SMN2AKR1B1KMT2AIDO1DPP4
SCHEMBL3148086 0.85 SMN1; SMN2 (0.46) SMN1; SMN2TAAR1AKR1B1KMT2AIDO1
SCHEMBL17055847 0.85 KDM4E (0.53) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL28905460 0.84 SMN1; SMN2 (0.40) SMN1; SMN2TAAR1AKR1B1IDO1KDM4E
SCHEMBL925766 0.82 SMN1; SMN2 (0.43) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL10457899 0.82 TAAR1 (0.43) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL15614733 0.80 ADRB2 (0.49) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL19879617 0.80 SMN1; SMN2 (0.42) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL4250565 0.80 AKR1B1 (0.48) SMN1; SMN2TAAR1AKR1B1KMT2AKDM4E
SCHEMBL13108637 0.79 SMN1; SMN2 (0.48) SMN1; SMN2TAAR1AKR1B1KMT2AIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 308 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108623561-B Method for preparing panenonic acid compound 中国海洋大学 2025-04-01 CN claimed
WO-2021216722-A1 STEREOSELECTIVE PROCESS OF MANUFACTURE OF PURINE PHOSPHORAMIDATES Atea Pharmaceuticals, Inc. (US) 2021-10-28 WO claimed
US-12551570-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2026-02-17 US disclosed
US-12479927-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2025-11-25 US disclosed
EP-4604951-A1 1-(SULFONYL)-N-PHENYLPYRROLIDINE-2-CARBOXAMIDES DERIVATIVES AND USE THEREOF AMIRA THERAPEUTICS, S.L. (ES) 2025-08-27 EP disclosed
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF INTOCELL, INC. (KR) 2025-07-03 US disclosed
CN-113454124-B9 Combination therapies for ARM and natural killer cells 克莱奥药品有限公司 2025-05-30 CN disclosed
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates INTOCELL, INC. (KR) 2025-04-15 US disclosed
CN-108623561-B Method for preparing panenonic acid compound 中国海洋大学 2025-04-01 CN disclosed
CN-113454124-B Combination therapies for ARM and natural killer cells 克莱奥药品有限公司 2025-03-11 CN disclosed
EP-4452328-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF Intocell, Inc. (KR) 2024-10-30 EP disclosed
WO-1987006594-A1 POLYAMIDE RESIN AND METHOD FOR PREPARATION OF REAGENTS FOR IMMUNODIAGNOSTIC USE SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH (US) 1987-11-05 WO disclosed
US-4617149-A ANIMAL GROWTH REGULATORS ELI LILLY AND COMPANY (US) 1986-10-14 US disclosed
EP-0044605-B1 FUNGICIDAL BIS-AZOLYL COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-02-12 EP disclosed
US-4523019-A INTERMEDIATE FOR FUNGICIDE AND PLANT GROWTH REGULATOR IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-06-11 US disclosed
EP-0138416-A2 Growth hormone release factor analogs ELI LILLY AND COMPANY (US) 1985-04-24 EP disclosed
US-4490364-A STIMULANTING GALL BLADDER CONTRACTION, ANTISECRETORY AGENT, ANTICONVULSANT THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1984-12-25 US disclosed
US-4416682-A 1,3-Bis(azolyl)propanols as fungicides and plant growth regulators IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-11-22 US disclosed
EP-0044605-A1 Fungicidal bis-azolyl compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-01-27 EP disclosed
US-3960828-A Catalytic hydrogenolysis of protected sulfur containing peptides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1976-06-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF CD47, TOP2A, SSB SMN1; SMN2 4272/4885TAAR1 4686/4885AKR1B1 3234/4885
US-12551570-B2 Compounds comprising cleavable linker and uses thereof FCGR2A, FCGR3B, FCGR1A SMN1; SMN2 3041/4885TAAR1 1883/4885AKR1B1 3724/4885
US-12479927-B2 Compounds comprising cleavable linker and uses thereof VIP, ANTXR2, TNFRSF9 SMN1; SMN2 2658/4885TAAR1 1935/4885AKR1B1 4402/4885
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates GABRA3, GABRA6, GABRA4 SMN1; SMN2 1564/4885TAAR1 365/4885AKR1B1 1338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.