Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953632 | 0.88 | HRH4 (0.54) | HTR6KDM4EMEN1KMT2AHTR1A | |
| Hydrochloric Acid SCHEMBL31414529 | 0.84 | HTR6 (0.50) | HTR6ADRB1HTR5AKDM4EHTR3E | |
| SCHEMBL28583279 | 0.78 | ULK1 (0.62) | KDM4EMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL31414573 | 0.78 | TMEM97 (0.47) | KDM4EMEN1KMT2ASIGMAR1HTR1A | |
| SCHEMBL4173685 | 0.76 | HTR6 (0.56) | HTR6ADRB1HTR5AKDM4EHTR3E | |
| SCHEMBL7943312 | 0.75 | HRH4 (0.48) | KDM4EMEN1KMT2AHSD17B10HRH4 | |
| SCHEMBL6607261 | 0.74 | HTR6 (0.50) | HTR6ADRB1HTR5AKDM4EHTR3E | |
| SCHEMBL20535848 | 0.74 | KIF11 (0.46) | KDM4EMEN1KMT2ACYP1A2HSD17B10 | |
| SCHEMBL915460 | 0.74 | HRH4 (0.55) | KDM4EMEN1KMT2ACYP1A2HSD17B10 | |
| SCHEMBL30310659 | 0.74 | HRH4 (0.55) | KDM4EMEN1KMT2ACYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678090-B1 | PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 1998-10-14 | — | — | EP | disclosed |
| US-5627177-A | Piperazine derivatives | JOHN WYETH & BROTHER, LTD. (GB) | 1997-05-06 | — | — | US | disclosed |
| EP-0678090-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-10-25 | — | — | EP | disclosed |
| WO-1994015919-A1 | PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-07-21 | — | — | WO | disclosed |