SCHEMBL8657049

SCHEMBL8657049

O=C(NC(=O)c1ccccc1Cl)Nc1cc(Cl)c(Oc2ccc(Cl)cc2Cl)c(Cl)c1Cl

nearest known ligand 0.59

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.59
PYGL P06737 14/20 0.53
PNLIP P16233 1/20 0.49
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.43
PKM P14618 1/20 0.43
RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659159 0.91 GCGR (0.51) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL8660832 0.91 PNLIP (0.52) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL8667260 0.90 PYGL (0.53) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL8662597 0.89 GCGR (0.48) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL8673061 0.88 GCGR (0.44) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL10713421 0.87 KMT2A (0.47) GCGRPYGLPNLIPMEN1KMT2A
SCHEMBL8663060 0.86 PYGL (0.52) GCGRPYGLPNLIPNPC1POLB
SCHEMBL8664412 0.85 GCGR (0.55) GCGRPYGLPNLIPNPC1POLB
SCHEMBL8658823 0.84 PYGL (0.50) GCGRPYGLPNLIPNPC1POLB
SCHEMBL8663097 0.83 GCGR (0.55) GCGRPYGLPNLIPNPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed