Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661383 | 0.83 | MAPT (0.56) | MAPTKMT2ANR3C2MAPK1HDAC3 | |
| SCHEMBL16896754 | 0.78 | MAPT (0.62) | MAPTKMT2ACA1CA2NR3C2 | |
| SCHEMBL27510736 | 0.75 | NR3C2 (0.53) | KMT2ACA1CA2NR3C2KEAP1 | |
| SCHEMBL5700054 | 0.73 | KEAP1 (0.58) | KMT2ACA1CA2NR3C2KEAP1 | |
| SCHEMBL368343 | 0.70 | MAPT (1.00) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL14571964 | 0.70 | CA2 (0.54) | KMT2ACA1CA2NR3C2KEAP1 | |
| SCHEMBL7686771 | 0.70 | KEAP1 (0.50) | MAPTKMT2ACA1CA2NR3C2 | |
| SCHEMBL3847258 | 0.70 | MAPT (0.56) | MAPTKMT2ACA1CA2 | |
| SCHEMBL6642017 | 0.69 | MAPT (0.55) | MAPTKMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL216185 | 0.69 | PTPN1 (0.62) | KMT2ACA1CA2KEAP1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | disclosed |
| EP-0625516-A1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LIMITED (GB) | 1994-11-23 | — | — | EP | disclosed |