Proflavine — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CALCRL CHRM1 CHRM2 CHRM3 F2R MAOA MAOB MAP2K1 MAP2K2 NTRK1 NTRK2 NTRK3 OPRD1 OPRK1 OPRM1 P2RY12 PKLR SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SLC18A2 SLC6A2 SLC6A3 TLR7 TLR9 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 dacA dacB dacC folA ftsI mrcA mrcB mrdA pol rplA rplB rplC rplD rplE rplF rplI rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmB1 rpmB2 rpmC rpmD rpmE rpmE2 rpmF rpmG rpmG1 rpmG2 rpmH rpmI rpmJ rpmJ2 rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsR1 rpsR2 rpsS rpsT rpsU rpsZ ykgM ykgO

The experimentally established mechanism targets of Proflavine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CHRM2 known ✓	P08172	1/20	0.72

▸	ADRA2A known ✓	P08913	1/20	0.72

▸	MAOA known ✓	P21397	1/20	0.72

▸	SLC6A2 known ✓	P23975	1/20	0.72

▸	OPRM1 known ✓	P35372	1/20	0.72

▸	SLC6A3 known ✓	Q01959	1/20	0.72

▸	LMNA	P02545	2/20	0.72

▸	MEN1	O00255	2/20	0.72

▸	KMT2A	Q03164	2/20	0.72

▸	HTT	P42858	2/20	0.72

▸	F2	P00734	1/20	0.72

▸	HTR1A	P08908	1/20	0.72

▸	ADORA3	P0DMS8	1/20	0.72

▸	DRD1	P21728	1/20	0.72

▸	ACHE	P22303	1/20	0.72

▸	PTGS1	P23219	1/20	0.72

▸	SLC6A4	P31645	1/20	0.72

▸	DRD3	P35462	1/20	0.72

▸	KDR	P35968	1/20	0.72

▸	KCNH2	Q12809	1/20	0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Proflavine SCHEMBL4257272	1.00	LMNA (0.72)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL592728	1.00	LMNA (0.72)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL27963470	1.00	LMNA (0.72)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL7081698	0.98	LMNA (0.75)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL22390813	0.98	LMNA (0.75)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL380278	0.98	LMNA (0.75)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL29360639	0.98	LMNA (0.75)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL27777227	0.98	LMNA (0.75)	LMNAMEN1KMT2AHTTF2
Sulfuric Acid SCHEMBL28530710	0.91	HTR3A (0.77)	LMNAMEN1KMT2AHTTF2
Proflavine SCHEMBL27777226	0.87	LMNA (0.64)	LMNAMEN1KMT2AHTTF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20250180952-A1	PHOTOALIGNING MATERIALS	Rolic Technologies AG (CH)	2025-06-05	—	—	US	disclosed
EP-4493638-A1	PHOTOALIGNING MATERIALS	Rolic Technologies AG (CH)	2025-01-22	—	—	EP	disclosed
CN-118027412-A	Photo-alignment material	罗利克技术有限公司	2024-05-14	—	—	CN	disclosed
WO-2023174773-A1	PHOTOALIGNING MATERIALS	Rolic Technologies AG (CH)	2023-09-21	—	—	WO	disclosed
US-11634544-B2	Photoaligning materials	Rolic Technologies AG (CH)	2023-04-25	—	—	US	disclosed
US-20210340330-A1	PHOTOALIGNING MATERIALS	Rolic Technologies AG (CH)	2021-11-04	—	—	US	disclosed
CN-108912011-B	Photoalignment material	罗立克科技股份公司	2021-09-24	—	—	CN	disclosed
CN-104649916-B	Photocrosslinkable materials	罗利克有限公司	2020-12-01	—	—	CN	disclosed
US-20200223984-A1	PHOTOALIGNING MATERIALS	Rolic Technologies AG (CH)	2020-07-16	—	—	US	disclosed
US-10696795-B2	Photoaligning materials	Rolic Technologies AG (CH)	2020-06-30	—	—	US	disclosed
US-20120076952-A1	PHOTOCROSSLINKABLE MATERIALS	ROLIC AG (CH)	2012-03-29	—	—	US	disclosed
EP-2308827-A1	Photocrosslinkable materials	Rolic AG (CH)	2011-04-13	—	—	EP	disclosed
EP-2308826-A1	Photocrosslinkable materials	Rolic AG (CH)	2011-04-13	—	—	EP	disclosed
EP-2305632-A1	Photocrosslinkable materials	Rolic AG (CH)	2011-04-06	—	—	EP	disclosed
EP-2305631-A1	Photocrosslinkable materials	Rolic AG (CH)	2011-04-06	—	—	EP	disclosed
US-20100266814-A1	PHOTOALIGNMENT COMPOSITION	ROLIC AG (CH)	2010-10-21	—	—	US	disclosed
EP-2222815-A1	PHOTOALIGNMENT COMPOSITION	Rolic Ltd. (CH)	2010-09-01	—	—	EP	disclosed
US-20100048849-A1	PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP	ROLIC AG (CH)	2010-02-25	—	—	US	disclosed
WO-2009080271-A1	PHOTOALIGNMENT COMPOSITION	ROLIC LTD. (CH)	2009-07-02	—	—	WO	disclosed
US-20080293888-A1	Photocrosslinkable Materials	ROLIC AG (CH)	2008-11-27	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20100048849-A1	PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP	DDC, ALAD, DYNC1LI1	CHRM2 4722/4885ADRA2A 4746/4885MAOA 588/4885
US-20080293888-A1	Photocrosslinkable Materials	DDC, PARG, ALAD	CHRM2 4691/4885ADRA2A 4803/4885MAOA 285/4885
US-20120076952-A1	PHOTOCROSSLINKABLE MATERIALS	DDC, PARG, ALAD	CHRM2 4691/4885ADRA2A 4803/4885MAOA 285/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.