Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6858149 | 0.88 | OPRK1 (0.38) | L3MBTL1ALDH1A1LMNARAB9AHPGD | |
| SCHEMBL8659654 | 0.79 | RIPK1 (0.36) | ALDH1A1KMT2AMEN1RIPK1PIK3CD | |
| SCHEMBL8662712 | 0.77 | RIPK1 (0.38) | LMNAKMT2AMEN1RIPK1PIK3CD | |
| SCHEMBL8661350 | 0.77 | ITGA4 (0.41) | MAPTTDP1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL8660376 | 0.77 | RIPK1 (0.37) | MAPTLMNAKMT2AMEN1RIPK1 | |
| SCHEMBL8807967 | 0.76 | GAA (0.35) | MAPTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8660036 | 0.76 | RIPK1 (0.34) | RIPK1PIK3CD | |
| SCHEMBL8662095 | 0.75 | PIK3CD (0.40) | KMT2AMEN1RIPK1PIK3CD | |
| SCHEMBL8660383 | 0.74 | SIGMAR1 (0.40) | L3MBTL1ALDH1A1KMT2AMEN1RIPK1 | |
| SCHEMBL8662813 | 0.71 | KMT2A (0.36) | HPGDKMT2AMEN1RIPK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |