SCHEMBL866209

SCHEMBL866209

CC(C)(C)N[C@H]1CCN(C(=O)O)C1

nearest known ligand 0.42

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.42
ALDH1A1 P00352 1/20 0.40
EPHX2 P34913 4/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
EPHX1 P07099 2/20 0.36
HSD11B1 P28845 3/20 0.35
CYP2C9 P11712 1/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
USP30 Q70CQ3 1/20 0.34
KDM5A P29375 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1439006 1.00 LMNA (0.42) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1
SCHEMBL376155 1.00 LMNA (0.42) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1
SCHEMBL2430897 0.89 CA1 (0.46) LMNAALDH1A1EPHX2EPHX1CA1
SCHEMBL1406056 0.89 CA1 (0.46) LMNAALDH1A1EPHX2EPHX1CA1
SCHEMBL376390 0.89 CA1 (0.46) LMNAALDH1A1EPHX2EPHX1CA1
SCHEMBL3053679 0.89 LMNA (0.44) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1
SCHEMBL1563474 0.88 HTT (0.43) LMNAALDH1A1EPHX2EPHX1CA1
SCHEMBL12404075 0.85 EPHX2 (0.49) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1
SCHEMBL12404070 0.85 EPHX2 (0.49) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1
SCHEMBL14440773 0.85 EPHX2 (0.49) LMNAALDH1A1EPHX2SMN1; SMN2EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260042764-A1 COMPOSITIONS AND METHODS FOR INHIBITION OF KRAS THERAS INC (US) 2026-02-12 US disclosed
US-20250136595-A1 ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2025-05-01 US disclosed
US-20240002375-A1 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TRE REMIX THERAPEUTICS INC. 2024-01-04 US disclosed
CN-117015536-A 2- (indazol-5-yl) -6- (piperidin-4-yl) -1, 7-naphthyridine derivatives and related compounds as modulators of nucleic acid splicing and treatment of proliferative diseases 雷密克斯医疗公司 2023-11-07 CN disclosed
WO-2022234867-A1 SULFONAMIDE HAVING MMP 7-INHIBITING ACTION 大正製薬株式会社 2022-11-10 WO disclosed
US-20210147432-A1 BENZODIAZOLIUM COMPOUNDS AS ENAC INHIBITORS Enterprise Therapeutics Limited (GB) 2021-05-20 US disclosed
US-9908895-B2 Tricyclic fused thiophene derivatives as JAK inhibitors INCYTE CORPORATION (US) 2018-03-06 US disclosed
US-20160024109-A1 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS INCYTE HOLDINGS CORPORATION 2016-01-28 US disclosed
US-20160015695-A1 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS INCYTE CORPORATION 2016-01-21 US disclosed
US-8680108-B2 Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors INCYTE CORPORATION (US) 2014-03-25 US disclosed
US-20120077781-A1 FLAVIN DERIVATIVES GADWOOD ROBERT (US) 2012-03-29 US disclosed
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS INCYTE CORPORATION 2011-07-28 US disclosed
EP-2274288-A2 MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS Incyte Corporation (US) 2011-01-19 EP disclosed
US-7795256-B2 Thieno-pyridinone derivatives as kinase inhibitors UCB PHARMA S.A. (BE) 2010-09-14 US disclosed
US-20070078131-A1 Thieno-pyridinone derivatives as kinase inhibitors CELLTECH R&D LIMITED (GB) 2007-04-05 US disclosed
US-20060247269-A1 Thienopyridone derivatives as kinase inhibitors UCB PHARMA S.A. (BE) 2006-11-02 US disclosed
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABBOTT LABORATORIES 2005-02-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250136595-A1 ACYLATED HETEROCYCLIC QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ERBB2, ERBB3, ERBB4 LMNA 4363/4885ALDH1A1 2574/4885EPHX2 3658/4885
US-20160015695-A1 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS JAK1, JAK3, JAK2 LMNA 4881/4885ALDH1A1 4431/4885EPHX2 3667/4885
US-20110183985-A1 SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS PIK3R1, PIK3R3, PIK3R2 LMNA 4440/4885ALDH1A1 3722/4885EPHX2 2483/4885
US-20240002375-A1 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TRE POLRMT, HNRNPA1, SNRPA LMNA 82/4885ALDH1A1 1243/4885EPHX2 3835/4885
US-20060247269-A1 Thienopyridone derivatives as kinase inhibitors MAPKAPK2, MAP3K6, MAP3K12 LMNA 4433/4885ALDH1A1 2307/4885EPHX2 3060/4885
US-20050026944-A1 Thienopyridine and furopyridine kinase inhibitors ABL1, ERBB2, LCK LMNA 4652/4885ALDH1A1 1899/4885EPHX2 2176/4885
US-20160024109-A1 TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS JAK1, JAK3, JAK2 LMNA 4881/4885ALDH1A1 4431/4885EPHX2 3667/4885
US-20210147432-A1 BENZODIAZOLIUM COMPOUNDS AS ENAC INHIBITORS NHERF1, SCNN1B, SCNN1A LMNA 2568/4885ALDH1A1 1179/4885EPHX2 3856/4885
US-20260042764-A1 COMPOSITIONS AND METHODS FOR INHIBITION OF KRAS KRAS, NRAS, HRAS LMNA 1750/4885ALDH1A1 2677/4885EPHX2 778/4885
US-20070078131-A1 Thieno-pyridinone derivatives as kinase inhibitors MAP3K6, MAP4K2, MAP3K15 LMNA 2907/4885ALDH1A1 2586/4885EPHX2 1883/4885
US-20120077781-A1 FLAVIN DERIVATIVES BLVRB, FLAD1, FDPS LMNA 3529/4885ALDH1A1 807/4885EPHX2 1099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.