Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL148949 | 1.00 | NPC1 (0.35) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL16114711 | 0.95 | EPHX1 (0.36) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Trimethylammonium SCHEMBL1707073 | 0.91 | ACHE (0.41) | EPHX1CA12CA14 | |
| Trimethylammonium SCHEMBL3681377 | 0.87 | TGFBR1 (0.36) | ALDH1A1TGFBR1 | |
| Trimethylammonium SCHEMBL5454852 | 0.87 | TGFBR1 (0.36) | ALDH1A1TGFBR1 | |
| Trimethylammonium SCHEMBL21743 | 0.86 | NPC1 (0.42) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15846659 | 0.85 | ACHE (0.44) | EPHX1CA12CA14 | |
| Trimethylammonium SCHEMBL3277856 | 0.85 | NPC1 (0.37) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Sulfuric Acid SCHEMBL11210945 | 0.84 | EPHX1 (0.41) | NPC1GAAMAPTRAB9ASMN1; SMN2 | |
| Trimethylammonium SCHEMBL635942 | 0.84 | NPC1 (0.41) | NPC1GAAMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791058-B2 | Composition for household care containing a cationic nanogel | RHODIA OPERATIONS (FR) | 2014-07-29 | — | — | US | claimed |
| EP-2346974-B1 | COMPOSITION FOR HOUSEHOLD CARE CONTAINING A CATIONIC NANOGEL | RHODIA OPERATIONS (FR) | 2014-06-04 | — | — | EP | claimed |
| EP-2160416-B1 | POLYMERIC MICROGEL COMPRISING CATIONIC UNITS | RHODIA OPERATIONS (FR) | 2013-05-01 | — | — | EP | claimed |
| US-20110271460-A1 | COMPOSITION FOR HOUSEHOLD CARE CONTAINING A CATIONIC NANOGEL | RHODIA OPERATIONS (FR) | 2011-11-10 | — | — | US | claimed |
| CN-113163757-B | Use of guar derivatives in biofungicide compositions | 罗地亚经营管理公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117440795-A | Rinse-free personal care compositions | 宝洁公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-117202888-A | Multiphase liquid compositions with improved deposition of active ingredients | 法国特种经营公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-117202887-A | Compositions comprising a multi-tail surfactant and a cationic polymer and uses thereof | 法国特种经营公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116322631-A | Low surfactant cosmetic composition comprising cationic polymer | 宝洁公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116322630-A | Surfactant-free cosmetic composition comprising cationic polymer | 宝洁公司 | 2023-06-23 | — | — | CN | disclosed |
| EP-2861706-B1 | FABRIC CONDITIONING COMPOSITION AND USE THEREOF | RHODIA OPERATIONS (FR) | 2017-12-06 | — | — | EP | disclosed |
| US-20150197708-A1 | Fabric Conditioning Composition And Use Thereof | RHODIA OPERATIONS (FR) | 2015-07-16 | — | — | US | disclosed |
| US-6235835-B1 | STARCH IS MODIFIED WITH AT LEAST ONE CATIONIC POLYMER | BASF AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | disclosed |
| WO-2000060167-A1 | MODIFYING STARCH WITH CATIONIC POLYMERS AND USE OF THE MODIFIED STARCHES AS DRY-STRENGTH AGENT | BASF AKTIENGESELLSCHAFT (DE) | 2000-10-12 | — | — | WO | disclosed |
| EP-0972110-A1 | METHOD FOR PRODUCING HIGH DRY-STRENGTH PAPER, PULPBOARD AND CARDBOARD | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-19 | — | — | EP | disclosed |
| US-5851300-A | Cationic modification of starch and use of the cationically modified starch | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-22 | — | — | US | disclosed |
| WO-1998045536-A1 | METHOD FOR PRODUCING HIGH DRY-STRENGTH PAPER, PULPBOARD AND CARDBOARD | BASF AKTIENGESELLSCHAFT (DE) | 1998-10-15 | — | — | WO | disclosed |
| EP-0788516-B1 | CATIONIC MODIFICATION PROCESS FOR STARCH AND USE OF CATIONICALLY MODIFIED STARCH | BASF AG (DE) | 1998-07-29 | — | — | EP | disclosed |
| EP-0788516-A1 | CATIONIC MODIFICATION PROCESS FOR STARCH AND USE OF CATIONICALLY MODIFIED STARCH | BASF AKTIENGESELLSCHAFT (DE) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013525-A1 | CATIONIC MODIFICATION PROCESS FOR STARCH AND USE OF CATIONICALLY MODIFIED STARCH | BASF AKTIENGESELLSCHAFT (DE) | 1996-05-09 | — | — | WO | disclosed |