Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8481555 | 0.98 | LMNA (0.37) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8653114 | 0.88 | CCR3 (0.42) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8482395 | 0.88 | MAPT (0.38) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8665945 | 0.86 | PGR (0.34) | L3MBTL1PGRDRD2KMT2A | |
| SCHEMBL8486150 | 0.84 | PGR (0.32) | PGRDRD2 | |
| SCHEMBL8485062 | 0.81 | MAPT (0.40) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8668018 | 0.78 | MAPT (0.39) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8717983 | 0.77 | CCR3 (0.43) | LMNAMAPTCCR3TSHRNPSR1 | |
| SCHEMBL8483684 | 0.77 | NPSR1 (0.41) | LMNAMAPTCCR3NPSR1DRD2 | |
| SCHEMBL8650737 | 0.77 | POLB (0.32) | LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |