SCHEMBL8662941

SCHEMBL8662941

C=CC(=O)Oc1ccccc1.N#CC(C(N)=O)=C1NS(=O)(=O)c2ccccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
CYP2C19 P33261 1/20 0.41
HSD11B1 P28845 1/20 0.38
KMT2A Q03164 2/20 0.36
LMNA P02545 2/20 0.36
KDM4E B2RXH2 2/20 0.36
CA12 O43570 1/20 0.36
USP2 O75604 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
BCHE P06276 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7766936 0.85 KDM4E (0.49) CYP1A2CYP3A4CYP2C9HPGDCYP2C19
SCHEMBL8386766 0.77 MAPT (0.34) HSD11B1KMT2ALMNAKDM4ECA12
SCHEMBL8659089 0.76 KDM4E (0.50) CYP1A2CYP3A4CYP2C9HPGDCYP2C19
SCHEMBL8600148 0.72 HSD11B1 (0.57) HPGDHSD11B1KMT2ALMNAKDM4E
SCHEMBL8634503 0.72 KDM4E (0.49) CYP1A2CYP3A4CYP2C9HPGDCYP2C19
Water SCHEMBL27707576 0.69 THRB (0.56) CYP3A4HPGDKMT2AKDM4EHSD17B10
SCHEMBL8390814 0.68 PTGES (0.39) CYP1A2CYP3A4CYP2C9HPGDCYP2C19
Hydrogen Peroxide SCHEMBL28479331 0.68 THRB (0.58) CYP3A4HPGDKMT2AKDM4EHSD17B10
SCHEMBL28916 0.68 THRB (0.58) CYP3A4HPGDKMT2AKDM4EHSD17B10
SCHEMBL8410384 0.67 MEN1 (0.45) HPGDHSD11B1KMT2ALMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5750305-A Poly (2-(sulfonamidomethylene)-2-cyanoacetamido)phenyl acrylate! charge-control agents for electrostatographic toners and developers EASTMAN KODAK COMPANY (US) 1998-05-12 US disclosed