SCHEMBL2519476

SCHEMBL2519476

c1ccc(Sc2ccc(C3=NC(c4ccc(Sc5ccccc5)cc4)(C4(c5ccc(Sc6ccccc6)cc5)N=C(c5ccc(Sc6ccccc6)cc5)C(c5ccc(Sc6ccccc6)cc5)=N4)N=C3c3ccc(Sc4ccccc4)cc3)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.37
MAOB P27338 3/20 0.37
HPGD P15428 3/20 0.35
ALDH1A1 P00352 2/20 0.35
ALOX5 P09917 1/20 0.34
SLC6A4 P31645 1/20 0.33
PTGIR P43119 1/20 0.31
ABCG2 Q9UNQ0 1/20 0.31
CHRNA7 P36544 1/20 0.31
MAPT P10636 3/20 0.31
HTT P42858 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
LMNA P02545 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
BCL2 P10415 1/20 0.30
MCL1 Q07820 1/20 0.30
DHODH Q02127 1/20 0.30
MGLL Q99685 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL490734 0.82 ALDH1A1 (0.41) ALDH1A1SLC6A4HSD17B10
SCHEMBL8666419 0.80 PTGS2 (0.45) ALDH1A1MAPT
SCHEMBL491001 0.78 MAOA (0.45) MAOAMAOBALOX5SLC6A4HSD17B10
SCHEMBL490735 0.78 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2MGLLHSD17B10
SCHEMBL491053 0.78 ALDH1A1 (0.39) ALDH1A1HTTSMN1; SMN2LMNA
SCHEMBL490744 0.73 NPY5R (0.44) ALDH1A1ALOX5ABCG2MAPTHTT
SCHEMBL8664748 0.73 CYP1A2 (0.48) HPGDALDH1A1MAPTHTTSMN1; SMN2
SCHEMBL14973574 0.73 NPC1 (0.41) HPGDALDH1A1MAPTSMN1; SMN2LMNA
SCHEMBL5554839 0.73 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2NPSR1MCL1
SCHEMBL2754909 0.72 MAOA (0.54) MAOAMAOBHPGDALDH1A1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8632937-B2 UV-sensitive lithographic printing plate precursor with benzoxazole derivative and analogues thereof as sensitizer EASTMAN KODAK COMPANY (US) 2014-01-21 US disclosed
US-8034538-B2 Negative-working imageable elements EASTMAN KODAK COMPANY (US) 2011-10-11 US disclosed
US-20100291355-A1 UV-SENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR WITH BENZOXAZOLE DERIVATIVE AND ANALOGUES THEREOF AS SENSITIZER KODAK REALTY INC. 2010-11-18 US disclosed
US-20100209846-A1 NEGATIVE-WORKING IMAGEABLE ELEMENTS EASTMAN KODAK COMPANY 2010-08-19 US disclosed
EP-1987396-B1 UV-SENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR WITH BENZOXAZOLE DERIVATIVE AND ANALOGUES THEREOF AS SENSITIZER KODAK GRAPHIC COMM GMBH (DE) 2010-05-26 EP disclosed
US-7615323-B2 Lithographic printing plate precursors with oligomeric or polymeric sensitizers KODAK GRAPHIC COMMUNICATIONS, GMBH (DE) 2009-11-10 US disclosed
EP-1849042-B1 PROCESS FOR THE PRODUCTION OF LITHOGRAPHIC PRINTING PLATES KODAK GRAPHIC COMM GMBH (DE) 2008-12-10 EP disclosed
US-20080145790-A1 Process for Production of Lithographic Printing Plates KODAK POLYCHROME GRAPHICS, GMBH (DE) 2008-06-19 US disclosed
EP-1921500-A1 UV-sensitive elements with triarylamine derivatives as sensitizers EASTMAN KODAK COMPANY (US) 2008-05-14 EP disclosed
US-20070269745-A1 Lithographic Printing Plate Precursors with Oligomeric Or Polymeric Sensitizers KODAK POLYCHROME GRAPHICS GMBH (DE) 2007-11-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100291355-A1 UV-SENSITIVE LITHOGRAPHIC PRINTING PLATE PRECURSOR WITH BENZOXAZOLE DERIVATIVE AND ANALOGUES THEREOF AS SENSITIZER MLX, CYP4X1, MMS19 MAOA 1662/4885MAOB 2103/4885HPGD 925/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.