SCHEMBL866564

SCHEMBL866564

Cc1ccc(N)c(C(=O)Nc2ccc(C(F)(F)F)cc2N)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 2/20 0.49
TMPRSS4 Q9NRS4 2/20 0.49
CFTR P13569 1/20 0.48
RXFP1 Q9HBX9 2/20 0.47
PTGS1 P23219 4/20 0.47
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
RAB9A P51151 2/20 0.45
TP53 P04637 1/20 0.45
MAPT P10636 1/20 0.45
NTRK1 P04629 1/20 0.45
NTRK2 Q16620 1/20 0.45
TSHR P16473 1/20 0.44
HDAC2 Q92769 1/20 0.44
TRPV1 Q8NER1 1/20 0.44
KCNMA1 Q12791 1/20 0.44
SORT1 Q99523 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23992191 0.80 HDAC3 (0.52) CFTRPTGS1KDM4EALDH1A1HPGD
SCHEMBL18839947 0.79 MAPT (0.56) P2RX1RXFP1KDM4EALDH1A1SMN1; SMN2
SCHEMBL16060789 0.78 KDM4E (0.57) CFTRPTGS1KDM4EALDH1A1HPGD
SCHEMBL2235637 0.77 CYP1A2 (0.55) CFTRRXFP1PTGS1KDM4EALDH1A1
SCHEMBL14363357 0.76 TMPRSS4 (0.74) P2RX1TMPRSS4RXFP1TSHRTRPV1
SCHEMBL21381352 0.75 RAB9A (0.60) P2RX1TMPRSS4RXFP1KDM4EALDH1A1
SCHEMBL30602919 0.75 RAB9A (0.60) P2RX1TMPRSS4RXFP1KDM4EALDH1A1
SCHEMBL30033648 0.75 CRHR1 (0.48) P2RX1RXFP1SORT1
SCHEMBL28477629 0.75 PTGS1 (0.64) P2RX1TMPRSS4RXFP1PTGS1KDM4E
SCHEMBL14568587 0.75 CFTR (0.51) CFTRPTGS1KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11634544-B2 Photoaligning materials Rolic Technologies AG (CH) 2023-04-25 US disclosed
US-20210340330-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2021-11-04 US disclosed
CN-108912011-B Photoalignment material 罗立克科技股份公司 2021-09-24 CN disclosed
US-20200223984-A1 PHOTOALIGNING MATERIALS Rolic Technologies AG (CH) 2020-07-16 US disclosed
US-10696795-B2 Photoaligning materials Rolic Technologies AG (CH) 2020-06-30 US disclosed
EP-3374467-B1 COMPOSITIONS OF PHOTO-ALIGNABLE MATERIALS ROLIC TECH AG (CH) 2020-04-15 EP disclosed
US-10558089-B2 Photoalignment composition ROLIC AG (CH) 2020-02-11 US disclosed
EP-2222815-B1 PHOTOALIGNMENT COMPOSITION ROLIC TECH AG (CH) 2019-05-29 EP disclosed
CN-109804306-A Light orientation copolymer material 罗利克技术有限公司 2019-05-24 CN disclosed
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group ROLIC AG (CH) 2019-02-19 US disclosed
EP-2305632-A1 Photocrosslinkable materials Rolic AG (CH) 2011-04-06 EP disclosed
US-20100266814-A1 PHOTOALIGNMENT COMPOSITION ROLIC AG (CH) 2010-10-21 US disclosed
EP-2222815-A1 PHOTOALIGNMENT COMPOSITION Rolic Ltd. (CH) 2010-09-01 EP disclosed
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2010-02-25 US disclosed
EP-2152660-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP Rolic AG (CH) 2010-02-17 EP disclosed
WO-2009080271-A1 PHOTOALIGNMENT COMPOSITION ROLIC LTD. (CH) 2009-07-02 WO disclosed
WO-2008145225-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2008-12-04 WO disclosed
US-20080293888-A1 Photocrosslinkable Materials ROLIC AG (CH) 2008-11-27 US disclosed
EP-1966119-A1 PHOTOCROSSLINKABLE MATERIALS Rolic AG (CH) 2008-09-10 EP disclosed
WO-2007071091-A1 PHOTOCROSSLINKABLE MATERIALS ROLIC AG (CH) 2007-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group DDC, ALAD, DYNC1LI1 P2RX1 4631/4885TMPRSS4 3388/4885CFTR 4868/4885
US-20100048849-A1 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP DDC, ALAD, DYNC1LI1 P2RX1 4631/4885TMPRSS4 3388/4885CFTR 4868/4885
US-20080293888-A1 Photocrosslinkable Materials DDC, PARG, ALAD P2RX1 4531/4885TMPRSS4 3362/4885CFTR 4836/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.