Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | TLR2 | O60603 | 4/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 4/20 | 0.36 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.35 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670628 | 0.91 | SIGMAR1 (0.41) | SIGMAR1TLR2TLR1NPFFR1NPFFR2 | |
| SCHEMBL8671320 | 0.89 | SIGMAR1 (0.41) | HDAC8SIGMAR1NAMPTTLR2TLR1 | |
| SCHEMBL8671876 | 0.88 | SIGMAR1 (0.37) | SIGMAR1TLR2TLR1 | |
| SCHEMBL8668252 | 0.85 | SIGMAR1 (0.39) | SIGMAR1TLR2TLR1MEN1KMT2A | |
| SCHEMBL8666222 | 0.83 | SIGMAR1 (0.40) | SIGMAR1TLR2TLR1MEN1KMT2A | |
| SCHEMBL8670608 | 0.81 | SIGMAR1 (0.38) | HDAC8SIGMAR1NPFFR1NPFFR2KMT2A | |
| SCHEMBL8668739 | 0.79 | ACE (0.47) | SIGMAR1TLR2TLR1NPFFR1NPFFR2 | |
| SCHEMBL8871032 | 0.76 | ACE (0.46) | SIGMAR1 | |
| SCHEMBL8668227 | 0.75 | SIGMAR1 (0.42) | SIGMAR1TLR2TLR1KMT2ARAB9A | |
| SCHEMBL8666972 | 0.75 | ACE (0.41) | MEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |