Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.34 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670628 | 0.88 | SIGMAR1 (0.41) | SIGMAR1CTSSTSHRCTSKMEN1 | |
| SCHEMBL8667685 | 0.83 | HDAC8 (0.38) | SIGMAR1TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL8668252 | 0.82 | SIGMAR1 (0.39) | SIGMAR1CTSSTSHRCTSKMEN1 | |
| SCHEMBL8671876 | 0.82 | SIGMAR1 (0.37) | SIGMAR1CTSSCTSKTLR2TLR1 | |
| SCHEMBL8672121 | 0.82 | SIGMAR1 (0.45) | SIGMAR1TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL8668716 | 0.81 | FKBP1A (0.39) | CTSSTSHRATMKDM1ACTSL | |
| SCHEMBL8670608 | 0.78 | SIGMAR1 (0.38) | SIGMAR1CTSSCTSKKMT2AL3MBTL1 | |
| SCHEMBL8668739 | 0.76 | ACE (0.47) | SIGMAR1TSHRKDM1AMEN1ALDH1A1 | |
| SCHEMBL8666218 | 0.76 | SIGMAR1 (0.35) | SIGMAR1ADRB2ADRB1ADRB3CTSS | |
| SCHEMBL8668231 | 0.75 | SIGMAR1 (0.41) | SIGMAR1TSHRMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |