Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 6/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 6/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670628 | 0.89 | SIGMAR1 (0.41) | SIGMAR1TLR2TLR1ACECTSS | |
| SCHEMBL8667685 | 0.88 | HDAC8 (0.38) | SIGMAR1TLR2TLR1 | |
| SCHEMBL8672106 | 0.84 | LMNA (0.37) | SIGMAR1ACE | |
| SCHEMBL8668252 | 0.84 | SIGMAR1 (0.39) | SIGMAR1TLR2TLR1SYKACE | |
| SCHEMBL8666222 | 0.82 | SIGMAR1 (0.40) | SIGMAR1TLR2TLR1CTSSCTSK | |
| SCHEMBL8670608 | 0.79 | SIGMAR1 (0.38) | SIGMAR1ACECTSSCTSK | |
| SCHEMBL8668739 | 0.78 | ACE (0.47) | SIGMAR1TLR2TLR1ACE | |
| SCHEMBL8671320 | 0.77 | SIGMAR1 (0.41) | SIGMAR1TLR2TLR1ACE | |
| SCHEMBL8668622 | 0.75 | GPR119 (0.33) | GPR119 | |
| SCHEMBL8871032 | 0.75 | ACE (0.46) | SIGMAR1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |