Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 4/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717803 | 0.96 | CCR3 (0.40) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8504377 | 0.94 | MCHR1 (0.34) | CCR3MCHR1DRD2DRD4SLC6A12 | |
| SCHEMBL8665214 | 0.85 | MCHR1 (0.37) | CCR3MCHR1DRD2DRD4SLC6A12 | |
| SCHEMBL8665881 | 0.82 | DRD2 (0.37) | MCHR1DRD2DRD4AKT1 | |
| SCHEMBL8480060 | 0.82 | CCR3 (0.40) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8500944 | 0.80 | MCHR1 (0.34) | CCR3MCHR1DRD2DRD4SLC6A12 | |
| SCHEMBL8666097 | 0.80 | DRD2 (0.36) | MCHR1DRD2DRD4AKT1 | |
| SCHEMBL8501237 | 0.77 | MTTP (0.36) | DRD2DRD4 | |
| SCHEMBL8648478 | 0.76 | CCNE1 (0.37) | CCR3ALDH1A1 | |
| SCHEMBL8501050 | 0.75 | MTTP (0.36) | DRD2DRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |