Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 5/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8665214 | 0.96 | MCHR1 (0.37) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8500944 | 0.93 | MCHR1 (0.34) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8679135 | 0.85 | L3MBTL1 (0.36) | POLBKMT2A | |
| SCHEMBL8717803 | 0.84 | CCR3 (0.40) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8666046 | 0.82 | L3MBTL1 (0.34) | KMT2A | |
| SCHEMBL8479387 | 0.82 | RORC (0.36) | NPSR1 | |
| SCHEMBL8668034 | 0.82 | CCR3 (0.37) | CCR3MCHR1SLC6A12TMEM97SIGMAR1 | |
| SCHEMBL8665881 | 0.82 | DRD2 (0.37) | MCHR1POLBNPSR1KMT2A | |
| SCHEMBL8648478 | 0.82 | CCNE1 (0.37) | CCR3POLBCCNE1CDK2MEN1 | |
| SCHEMBL8504367 | 0.81 | KCNA5 (0.32) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-H1729-H | Method for preparing compounds employing solid phase synthesis and novel linker-resin | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| US-5739135-A | PREVENTING OR TREATING ATHEROSCLEROSIS, PANCREATITIS SECONDARY TO HYPERTRIGLYCERIDEMIA, HYPERGLYCEMIA, OBESITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-14 | — | — | US | disclosed |