SCHEMBL866856

SCHEMBL866856

OCCCCC(F)=C(F)F

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.39
FFAR1 O14842 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.32
LMNA P02545 2/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
TSHR P16473 1/20 0.32
CAMK2A Q9UQM7 1/20 0.30
FNTA P49354 1/20 0.30
FNTB P49356 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL864873 0.90
SCHEMBL17688222 0.87 LMNA (0.30) SMN1; SMN2LMNA
SCHEMBL4696009 0.76
SCHEMBL866855 0.73
SCHEMBL10627690 0.73 CES2 (0.46) GPR84FFAR1FFAR4ALDH1A1HSD17B10
SCHEMBL16499931 0.73 FOLH1 (0.43)
SCHEMBL5095696 0.73 TSHR (0.33) TSHR
SCHEMBL8018734 0.73
SCHEMBL4763770 0.71 SMN1; SMN2 (0.36) GPR84FFAR1FFAR4SMN1; SMN2KDM4E
SCHEMBL372685 0.71 CES2 (0.48) GPR84FFAR1FFAR4ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10750742-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-25 US claimed
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-02-13 US claimed
EP-3606918-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-02-12 EP claimed
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 US claimed
EP-3393245-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2018-10-31 EP claimed
WO-2018185187-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2018-10-11 WO claimed
WO-2017108569-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-06-29 WO claimed
US-10750742-B2 Pesticidally active pyrazole derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-08-25 US disclosed
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2020-02-13 US disclosed
EP-3606918-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2020-02-12 EP disclosed
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group ROLIC AG (CH) 2019-02-19 US disclosed
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2019-01-17 US disclosed
EP-3393245-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2018-10-31 EP disclosed
EP-0798285-A2 3,4,4-Trifluoro-3-butenoic acid or its methyl ester MONSANTO COMPANY (US) 1997-10-01 EP disclosed
US-5623084-A INSECTICIDES, MITICIDES MONSANTO COMPANY (US) 1997-04-22 US disclosed
US-5561162-A SYSTEMIC PESTICIDES; NEMATOCIDES; INSECTICIDES; MITICIDES; EFFICIENCY; CROPS MONSANTO COMPANY (US) 1996-10-01 US disclosed
US-5457134-A Controlling nematodes, insects, acarids on plants MONSANTO COMPANY (US) 1995-10-10 US disclosed
EP-0640069-A1 FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST REPELLENTS MONSANTO COMPANY (US) 1995-03-01 EP disclosed
US-5389680-A Insecticides, nematocides, miticides MONSANTO COMPANY (US) 1995-02-14 US disclosed
WO-1992015555-A2 FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST REPELLENTS MONSANTO COMPANY (US) 1992-09-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10208031-B2 Photocrosslinkable materials comprising alicyclic group DDC, ALAD, DYNC1LI1 GPR84 2594/4885FFAR1 1943/4885FFAR4 2221/4885
US-20190014783-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT GPR84 4078/4885FFAR1 3798/4885FFAR4 4371/4885
US-10750742-B2 Pesticidally active pyrazole derivatives ACHE, AADAC, CAT GPR84 4078/4885FFAR1 3798/4885FFAR4 4371/4885
US-20200048238-A1 PESTICIDALLY ACTIVE PYRAZOLE DERIVATIVES ACHE, AADAC, CAT GPR84 4026/4885FFAR1 3792/4885FFAR4 4364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.