Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668831 | 0.84 | TNF (0.39) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8669916 | 0.77 | ALDH1A1 (0.43) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8705206 | 0.75 | ALOX15 (0.39) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8668236 | 0.69 | MME (0.41) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL3278174 | 0.69 | LMNA (0.52) | LMNAACEMMECPA1ACE2 | |
| SCHEMBL3278180 | 0.69 | LMNA (0.52) | LMNAACEMMECPA1ACE2 | |
| SCHEMBL8704879 | 0.68 | KDM4E (0.43) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8704878 | 0.67 | ALOX15 (0.38) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8669962 | 0.66 | TNF (0.39) | TNFALDH1A1LMNAACEMME | |
| SCHEMBL8815317 | 0.65 | L3MBTL1 (0.52) | TNFALDH1A1LMNAACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849781-A | Tricyclic amides | ADIR ET COMPAGNIE (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5712312-A | MELATONINERGIC RECEPTOR LIGANDS, TREATMENT OF SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |