Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 12/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600310 | 0.74 | LCK (0.40) | RORCPIK3C2B | |
| SCHEMBL8602077 | 0.74 | ALDH1A1 (0.39) | RORCKMT2AUSP2PKMMEN1 | |
| SCHEMBL8670592 | 0.72 | KMT2A (0.38) | RORCKMT2AIRAK4PTGES | |
| SCHEMBL8602830 | 0.70 | TSHR (0.46) | IRAK4 | |
| SCHEMBL8598381 | 0.68 | ALDH1A1 (0.41) | RORCKMT2APTGESMEN1 | |
| SCHEMBL8670583 | 0.67 | TSHR (0.35) | RORCIRAK4 | |
| SCHEMBL8602584 | 0.65 | IRAK4 (0.44) | PIK3C2BIRAK4 | |
| SCHEMBL8670585 | 0.63 | P2RX7 (0.40) | — | |
| SCHEMBL8565463 | 0.62 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL8601990 | 0.62 | KMT2A (0.40) | KMT2APTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |