Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.35 |
| ▸ | CDK14 | O94921 | 1/20 | 0.32 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670592 | 0.70 | KMT2A (0.38) | TSHRKDM4EHSD17B10IRAK4MAPT | |
| SCHEMBL8598377 | 0.69 | ALDH1A1 (0.43) | TSHRALDH1A1POLB | |
| SCHEMBL8596742 | 0.69 | PTGES (0.36) | TSHRCDK14CCNYPOLB | |
| SCHEMBL8670588 | 0.67 | RORC (0.35) | IRAK4RORC | |
| SCHEMBL8670342 | 0.65 | MAPK8 (0.36) | TSHRKDM4EHSD17B10CDK14CCNY | |
| SCHEMBL8597839 | 0.64 | TYK2 (0.36) | TSHRKDM4EHSD17B10CDK14CCNY | |
| SCHEMBL8670585 | 0.62 | P2RX7 (0.40) | KDM4E | |
| SCHEMBL8565463 | 0.60 | IRAK4 (0.48) | TSHRIRAK4FLT3 | |
| SCHEMBL8602584 | 0.59 | IRAK4 (0.44) | IRAK4FLT3MAPT | |
| SCHEMBL8598882 | 0.59 | TYK2 (0.44) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |