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SCHEMBL8670870

SCHEMBL8670870

O=C1[N]C(=O)C(c2ccccc2)=C1c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 1/20 0.46
▸ MAPT P10636 2/20 0.46
▸ HTT P42858 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.44
▸ KMT2A Q03164 1/20 0.44
▸ P2RX7 Q99572 1/20 0.41
▸ NPC1 O15118 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ FGFR1 P11362 2/20 0.40
▸ FGFR2 P21802 2/20 0.40
▸ FGFR4 P22455 2/20 0.40
▸ FGFR3 P22607 2/20 0.40
▸ CFTR P13569 1/20 0.40
▸ GOPC Q9HD26 1/20 0.40
▸ MITF O75030 1/20 0.40
▸ NPSR1 Q6W5P4 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ PLA2G10 O15496 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL852224 0.73 ALDH1A1 (0.67) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL532969 0.73 ALDH1A1 (0.67) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL532970 0.73 ALDH1A1 (0.67) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL516326 0.73 PDE4B (0.54) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL10359088 0.72 PDE4B (0.39) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL592300 0.71 PTGS2 (0.65) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL57764 0.71 MAOA (0.52) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL20160837 0.71 PDE4B (0.52) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL8693759 0.71 PDE4B (0.52) PDE4BMAPTHTTLMNAALDH1A1
SCHEMBL13170491 0.71 PDE4B (0.52) PDE4BMAPTHTTLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005807-B2 Synthesis of sialylated/fucosylated human milk oligosaccharides GLYCOM A/S (DK) 2018-06-26 — — US claimed
US-20160075729-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES GLYCOM A/S (DK) 2016-03-17 — — US claimed
EP-2984096-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES Glycom A/S (DK) 2016-02-17 — — EP claimed
US-20140323705-A1 MANUFACTURE OF LACTO-N-TETRAOSE GLYCOM A/S (DK) 2014-10-30 — — US claimed
WO-2014167537-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED OLIGOSACCHARIDES GLYCOM A/S (DK) 2014-10-16 — — WO claimed
WO-2014167538-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES GLYCOM A/S (DK) 2014-10-16 — — WO claimed
WO-2013091660-A1 A METHOD FOR OBTAINING CRYSTALLINE LACTO-N-TETRAOSE AND LACTO-N-NEOTETRAOSE PRECURSORS AND MIXTURES THEREOF GLYCOM A/S (DK) 2013-06-27 — — WO claimed
WO-2012155916-A1 MANUFACTURE OF LACTO-N-TETRAOSE GLYCOM A/S (DK) 2012-11-22 — — WO claimed
EP-0468470-B1 Benzimidazoles, medicaments containing them and process for their preparation THOMAE GMBH DR K (DE) 1997-04-16 — — EP claimed
US-5252745-A Preparation and use of iodopropargyl esters of α-amino acid derivatives as antimicrobial agents ROHM AND HAAS COMPANY (US) 1993-10-12 — — US claimed
US-4958018-A REACTING A 3-HALOMETHYL-3-CEPHEM WITH A LEAD REDUCING AGENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1990-09-18 — — US claimed
US-10005807-B2 Synthesis of sialylated/fucosylated human milk oligosaccharides GLYCOM A/S (DK) 2018-06-26 — — US disclosed
US-20160075729-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES GLYCOM A/S (DK) 2016-03-17 — — US disclosed
EP-2984096-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES Glycom A/S (DK) 2016-02-17 — — EP disclosed
US-20140323705-A1 MANUFACTURE OF LACTO-N-TETRAOSE GLYCOM A/S (DK) 2014-10-30 — — US disclosed
US-4958018-A REACTING A 3-HALOMETHYL-3-CEPHEM WITH A LEAD REDUCING AGENT OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1990-09-18 — — US disclosed
US-4910194-A Structure substituted with phenyl group YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1990-03-20 — — US disclosed
EP-0342587-A2 Thienotriazolodiazepine compounds and pharmaceutical uses thereof YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1989-11-23 — — EP disclosed
EP-0341694-A2 Method for production of 3-exomethylenecepham derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1989-11-15 — — EP disclosed
EP-0315698-A1 THIENO(TRIAZOLO)DIAZEPINE COMPOUNDS AND MEDICINAL APPLICATION OF THE SAME YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1989-05-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160075729-A1 SYNTHESIS OF SIALYLATED/FUCOSYLATED HUMAN MILK OLIGOSACCHARIDES FUT6, ST6GAL1, FUCA1 PDE4B 4033/4885MAPT 3942/4885HTT 2815/4885
US-10005807-B2 Synthesis of sialylated/fucosylated human milk oligosaccharides FUT6, ST6GAL1, ST3GAL3 PDE4B 3710/4885MAPT 3818/4885HTT 1955/4885
US-20140323705-A1 MANUFACTURE OF LACTO-N-TETRAOSE FUT6, FUT5, ST6GAL1 PDE4B 4134/4885MAPT 1370/4885HTT 2197/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.