Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 3/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 3/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668231 | 0.90 | SIGMAR1 (0.41) | SIGMAR1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8668739 | 0.89 | ACE (0.47) | SIGMAR1L3MBTL1TLR2TLR1ACE | |
| SCHEMBL8668227 | 0.84 | SIGMAR1 (0.42) | SIGMAR1L3MBTL1TLR2TLR1ACE | |
| SCHEMBL8671320 | 0.83 | SIGMAR1 (0.41) | SIGMAR1TLR2TLR1ACEMEN1 | |
| SCHEMBL8666870 | 0.82 | SIGMAR1 (0.43) | SIGMAR1L3MBTL1MMP1MMP9MMP13 | |
| SCHEMBL8666222 | 0.82 | SIGMAR1 (0.40) | SIGMAR1L3MBTL1TLR2TLR1MEN1 | |
| SCHEMBL8669414 | 0.78 | SIGMAR1 (0.43) | SIGMAR1ACEHRH3PREP | |
| SCHEMBL8670628 | 0.78 | SIGMAR1 (0.41) | SIGMAR1L3MBTL1TLR2TLR1ACE | |
| SCHEMBL9005832 | 0.77 | USP30 (0.38) | ALDH1A1 | |
| SCHEMBL8871413 | 0.77 | ACE (0.48) | SIGMAR1L3MBTL1ACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707991-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, PARKINSON'S DISEASE | RHONE-POULENC RORER S.A. (FR) | 1998-01-13 | — | — | US | disclosed |