Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.48 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28347913 | 0.75 | SMN1; SMN2 (0.56) | KMT2APOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8680269 | 0.75 | PTGER1 (0.48) | LRRK2CCR5USP28USP25HTT | |
| SCHEMBL17700673 | 0.74 | USP28 (0.50) | CCR5USP28USP25HTTMTNR1B | |
| SCHEMBL8677028 | 0.74 | NPC1 (0.67) | USP28USP25KMT2AMTNR1BALDH1A1 | |
| SCHEMBL18892489 | 0.73 | LMNA (0.53) | CCR5USP28USP25HTTALDH1A1 | |
| SCHEMBL8676639 | 0.73 | USP28 (0.52) | CCR5USP28USP25KMT2AHTT | |
| SCHEMBL8323808 | 0.72 | CCR5 (0.47) | LRRK2CCR5USP28USP25HTT | |
| SCHEMBL16294058 | 0.72 | PTGER1 (0.64) | CCR5USP28USP25HTTALDH1A1 | |
| SCHEMBL8321883 | 0.72 | PTGER1 (0.47) | LRRK2CCR5USP28USP25HTT | |
| SCHEMBL8319969 | 0.72 | USP28 (0.53) | LRRK2CCR5USP28USP25KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811459-A | PAIN RELIEVERS | ZENECA LIMITED (GB) | 1998-09-22 | — | — | US | disclosed |