Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 11/20 | 1.00 |
| ▸ | AURKA | O14965 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | BACE1 | P56817 | 3/20 | 0.63 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | RECQL | P46063 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29647673 | 1.00 | P4HB (1.00) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL10391052 | 0.85 | P4HB (0.74) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL29647651 | 0.85 | P4HB (0.74) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL29728494 | 0.81 | MAPT (0.72) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL5175867 | 0.81 | MAPT (0.72) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL24389157 | 0.78 | P4HB (0.64) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL16879551 | 0.78 | P4HB (0.64) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL29440907 | 0.78 | MAPT (0.74) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL2957896 | 0.78 | AURKA (1.00) | P4HBAURKAAURKBBACE1MAOA | |
| SCHEMBL4304001 | 0.78 | MAPT (0.74) | P4HBAURKAAURKBBACE1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101712648-B | Synthesis method of azepine anthraquinone | NANJING UNIVERSITY OF TECHNOLOGY | 2011-11-09 | — | — | CN | claimed |
| CN-101712648-A | Synthesis method of azepine anthraquinone | NANJING UNIVERSITY OF TECHNOLOGY | 2010-05-26 | — | — | CN | claimed |
| US-20240018132-A1 | 5-HYDROXY-1,4-NAPHTHALENEDIONE FOR USE IN THE TREATMENT OF CANCER | GODAVARI BIOREFINERIES LTD. (IN) | 2024-01-18 | — | — | US | disclosed |
| US-20240018132-A1 | 5-HYDROXY-1,4-NAPHTHALENEDIONE FOR USE IN THE TREATMENT OF CANCER | GODAVARI BIOREFINERIES LTD. (IN) | 2024-01-18 | — | — | US | disclosed |
| US-20240018132-A1 | 5-HYDROXY-1,4-NAPHTHALENEDIONE FOR USE IN THE TREATMENT OF CANCER | GODAVARI BIOREFINERIES LTD. (IN) | 2024-01-18 | — | — | US | disclosed |
| CN-116670122-A | 5-hydroxy-1, 4-naphthalenediones for the treatment of cancer | 戈达瓦里生物炼制有限责任公司 | 2023-08-29 | — | — | CN | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| US-8703979-B2 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO., LTD. (JP) | 2014-04-22 | — | — | US | disclosed |
| EP-2555764-A1 | ANTIMICROBIAL COMPOUNDS OF 1,4- NAPHTOQUINONE STRUCTURE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2013-02-13 | — | — | EP | disclosed |
| CN-102432569-A | Novel process for the preparation of tricyclic compounds with anticancer activity via alkyne coupling reactions | TAHEEBO JAPAN CO LTD | 2012-05-02 | — | — | CN | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | TAHEEBO JAPAN CO., LTD. (JP) | 2012-03-29 | — | — | US | disclosed |
| CN-101712648-B | Synthesis method of azepine anthraquinone | NANJING UNIVERSITY OF TECHNOLOGY | 2011-11-09 | — | — | CN | disclosed |
| WO-2011124697-A1 | ANTIMICROBIAL COMPOUNDS OF 1,4- NAPHTOQUINONE STRUCTURE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011124697-A1 | ANTIMICROBIAL COMPOUNDS OF 1,4- NAPHTOQUINONE STRUCTURE | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2011-10-13 | — | — | WO | disclosed |
| CN-101712648-A | Synthesis method of azepine anthraquinone | NANJING UNIVERSITY OF TECHNOLOGY | 2010-05-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077986-A1 | NOVEL PREPARATION OF ANTICANCER-ACTIVE TRICYCLIC COMPOUNDS VIA ALKYNE COUPLING REACTION | NR2C2, NR0B2, NR4A2 | P4HB 2002/4885AURKA 507/4885AURKB 547/4885 |
| US-20240018132-A1 | 5-HYDROXY-1,4-NAPHTHALENEDIONE FOR USE IN THE TREATMENT OF CANCER | HSD17B11, HSD17B1, HSD3B1 | P4HB 3326/4885AURKA 660/4885AURKB 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.