Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8684069 | 0.73 | RAB9A (0.46) | ALDH1A1KDM4ELMNAHPGDL3MBTL1 | |
| SCHEMBL5971733 | 0.73 | HPGDS (0.55) | JAK2JAK3ALDH1A1KDM4ELMNA | |
| SCHEMBL11954569 | 0.67 | TOP2A (0.57) | ALDH1A1LMNAHPGDTDP1L3MBTL1 | |
| SCHEMBL8681986 | 0.66 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHPGDSMAPT | |
| SCHEMBL7377874 | 0.66 | TOP2A (0.53) | ALDH1A1LMNAHPGDTDP1L3MBTL1 | |
| SCHEMBL2564440 | 0.65 | ALDH1A1 (0.60) | JAK2JAK3ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL15714331 | 0.65 | TOP2A (0.52) | ALDH1A1LMNAHPGDTDP1L3MBTL1 | |
| SCHEMBL8682718 | 0.64 | MAPK1 (0.44) | JAK2CYP1A2MAPK1 | |
| SCHEMBL648130 | 0.64 | HPGDS (0.55) | JAK2JAK3ALDH1A1KDM4ELMNA | |
| SCHEMBL1602631 | 0.64 | TOP2A (0.56) | ALDH1A1KDM4ELMNACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760028-A | TREATING CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, MACULAR DEGENERATION | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-06-02 | — | — | US | disclosed |