Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.37 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL29558803 | 1.00 | HDAC8 (0.41) | HDAC8ACHEKDM4AKDM2AKDM4E | |
| SCHEMBL29461432 | 0.98 | HDAC8 (0.42) | HDAC8ACHEKDM4AKDM2AKDM4E | |
| SCHEMBL150282 | 0.98 | HDAC8 (0.42) | HDAC8ACHEKDM4AKDM2AKDM4E | |
| Water SCHEMBL8976458 | 0.96 | HDAC8 (0.40) | HDAC8ACHEKDM4AKDM2ANPC1 | |
| SCHEMBL1560289 | 0.94 | HDAC8 (0.41) | HDAC8ACHEKDM4AKDM2ANPC1 | |
| SCHEMBL7057933 | 0.89 | HDAC8 (0.44) | HDAC8ACHEKDM4EALDH1A1POLB | |
| SCHEMBL12223395 | 0.88 | HDAC8 (0.41) | HDAC8ACHEKDM4AKDM2AKDM4E | |
| Betaine SCHEMBL133669 | 0.85 | HDAC8 (0.35) | HDAC8ACHEALDH1A1 | |
| SCHEMBL17123054 | 0.84 | HDAC8 (0.46) | HDAC8ACHEKDM4AKDM2AKDM4E | |
| SCHEMBL29356904 | 0.84 | ALDH1A1 (0.48) | HDAC8ACHEKDM4AKDM2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100226823-A1 | Drying substances, preparation and use thereof | ORIDION MEDICAL (1987) LTD. (IL) | 2010-09-09 | — | — | US | claimed |
| EP-2226192-A1 | Drying substances, preparation and use thereof | Oridion Medical 1987 Ltd. (IL) | 2010-09-08 | — | — | EP | claimed |
| US-7604746-B2 | high-performance membrane designed for the selective removal of a polar fluid (water) from less polar fluids (organic solvents), by a pervaporation using a composite membrane contaiing ultrafiltration membrane as support ( e.g. cellulose acetate) and a crosslinked copolymer of anionic, cationic monomers | MCMASTER UNIVERSITY (CA) | 2009-10-20 | — | — | US | claimed |
| EP-1747059-A1 | PERVAPORATION COMPOSITE MEMBRANES | McMaster University (CA) | 2007-01-31 | — | — | EP | claimed |
| US-20060000778-A1 | high-performance membrane designed for the selective removal of a polar fluid (water) from less polar fluids (organic solvents), by a pervaporation using a composite membrane contaiing ultrafiltration membrane as support ( e.g. cellulose acetate) and a crosslinked copolymer of anionic, cationic monomers | MCMASTER UNIVERSITY (CA) | 2006-01-05 | — | — | US | claimed |
| WO-2005102503-A1 | PERVAPORATION COMPOSITE MEMBRANES | MCMASTER UNIVERSITY (CA) | 2005-11-03 | — | — | WO | claimed |
| US-20030161804-A1 | Self-adhesive cationic or amphoteric free-radical polymers and cosmetic use thereof | L'OREAL (FR) | 2003-08-28 | — | — | US | claimed |
| EP-0869766-B1 | COMPOSITIONS FOR THE TREATMENT OF KERATINIC MATERIALS CONTAINING THE ASSOCIATION OF A POLYAMPHOLYTE POLYMER AND A CATIONIC POLYMER | OREAL (FR) | 2001-11-21 | — | — | EP | claimed |
| EP-0889940-B1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING & MFG (US) | 2000-05-03 | — | — | EP | claimed |
| CN-1215423-A | Electroprayable release coating | MINNESOTA MINING & MFG (US) | 1999-04-28 | — | — | CN | claimed |
| EP-0889940-A1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-01-13 | — | — | EP | claimed |
| US-5858545-A | COMPRISING AN UNSATURATED MONOMER, A POLYSILOXANE HAVING UNSATURATED END GROUPS AND ONE OR MORE NONVOLATILE CONDUCTIVITY ENHANCER SOLUBLE IN THE MONOMER AND NOT INTERFERING WITH THE COPOLYMERIZATION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-01-12 | — | — | US | claimed |
| WO-1997035941-A1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-10-02 | — | — | WO | claimed |
| US-20260147278-A1 | ORGANIC UNDERLAYER AND METHODS FOR EUV DOSE REDUCTION | BREWER SCIENCE, INC. (US) | 2026-05-28 | — | — | US | disclosed |
| US-20250099918-A1 | COATED POROUS FILTER MEMBRANES AND RELATED METHODS | ENTEGRIS INC (US) | 2025-03-27 | — | — | US | disclosed |
| WO-2025064865-A1 | COATED POROUS FILTER MEMBRANES AND RELATED METHODS | ENTEGRIS, INC. (US) | 2025-03-27 | — | — | WO | disclosed |
| EP-0532687-B1 | SEMIPERMEABLE COMPOSITE MEMBRANE | TNO (NL) | 1996-04-17 | — | — | EP | disclosed |
| US-5348652-A | Ampholytic polymer | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1994-09-20 | — | — | US | disclosed |
| EP-0532687-A1 | SEMIPERMEABLE COMPOSITE MEMBRANE. | TNO (NL) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018666-A1 | SEMIPERMEABLE COMPOSITE MEMBRANE | NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO (NL) | 1991-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260147278-A1 | ORGANIC UNDERLAYER AND METHODS FOR EUV DOSE REDUCTION | PARG, KCNK9, PRDM9 | HDAC8 4271/4885ACHE 1501/4885KDM4A 25/4885 |
| US-20030161804-A1 | Self-adhesive cationic or amphoteric free-radical polymers and cosmetic use thereof | PARN, PCNA, F13A1 | HDAC8 2014/4885ACHE 690/4885KDM4A 2004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.