Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.31 |
| ▸ | MEN1 | O00255 | 5/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549583 | 0.84 | HIF1A (0.39) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL7146368 | 0.84 | ALDH1A1 (0.38) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL8551905 | 0.69 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL8549554 | 0.65 | HTR6 (0.42) | MAPTLMNAHTTKMT2AMEN1 | |
| SCHEMBL87387 | 0.57 | MAPT (0.51) | MAPTLMNAKMT2AMEN1PKM | |
| SCHEMBL9486183 | 0.57 | EIF4A1 (0.47) | MAPTKMT2AMEN1PKMTDP1 | |
| SCHEMBL15347383 | 0.56 | CDC25C (0.57) | MAPTLMNAHTTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9487425 | 0.56 | EIF4A1 (0.46) | MAPTKMT2AMEN1PKMTDP1 | |
| SCHEMBL9487419 | 0.56 | POLB (0.42) | MAPTLMNAKMT2AMEN1PKM | |
| SCHEMBL11180478 | 0.55 | MAPT (0.48) | MAPTHTTKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |