Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A1 | P60842 | 8/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BAD | Q92934 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9487425 | 0.99 | EIF4A1 (0.46) | EIF4A1GPR35ALDH1A1POLBKMT2A | |
| SCHEMBL9487419 | 0.89 | POLB (0.42) | EIF4A1ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL11180478 | 0.87 | MAPT (0.48) | ALDH1A1POLBKMT2AMEN1HPGD | |
| SCHEMBL9486042 | 0.84 | LMNA (0.41) | EIF4A1ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL1063565 | 0.80 | ALDH1A1 (0.56) | GPR35ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL11180853 | 0.80 | EIF4A1 (0.48) | EIF4A1ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL4652863 | 0.77 | GPR35 (0.59) | GPR35MCL1BCL2BCL2L1BAD | |
| SCHEMBL11799095 | 0.77 | SENP5 (0.44) | ALDH1A1POLBKMT2AMEN1PKM | |
| SCHEMBL9486378 | 0.77 | ESR1 (0.42) | — | |
| SCHEMBL6616990 | 0.76 | MCL1 (0.65) | GPR35ALDH1A1KMT2AMCL1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223510-A | ALKYLAMINOALKYL DERIVATIVES OF BENZOFURAN, BENZOTHIOPHENE, INDOLE AND INDOLIZINE, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANOFI (FR) | 1993-06-29 | — | — | US | disclosed |
| US-4410536-A | 7,8,9,10-Tetrahydrothieno[3,2-e]pyrido[4,3-b]indole compounds and their anti-depressant use | TROPONWERKE GMBH & CO. K.G. (DE) | 1983-10-18 | — | — | US | disclosed |