Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.42 |
| ▸ | HTR1D | P28221 | 4/20 | 0.42 |
| ▸ | HTR1B | P28222 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553359 | 0.84 | HIF1A (0.42) | HTR6HTTSMN1; SMN2MAPTMEN1 | |
| SCHEMBL7146842 | 0.84 | BRD4 (0.47) | HTR6HTR7HTR2BBRD4HTT | |
| SCHEMBL8931396 | 0.78 | BRD4 (0.48) | HTR6HTR7HTR2BBRD4HTT | |
| SCHEMBL8548267 | 0.74 | KDM4E (0.41) | HTTSMN1; SMN2MAPTKDM4EMEN1 | |
| SCHEMBL8554008 | 0.73 | BRAF (0.30) | — | |
| SCHEMBL8550889 | 0.73 | HTR6 (0.38) | HTR6SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12922863 | 0.63 | BRD4 (0.50) | HTR6BRD4HTTSMN1; SMN2KDM4E | |
| SCHEMBL3064389 | 0.61 | CES1 (0.54) | SMN1; SMN2MAPTMEN1ALDH1A1LMNA | |
| SCHEMBL8546895 | 0.61 | MEN1 (0.43) | HTR2CHTR2BHTTSMN1; SMN2MAPT | |
| SCHEMBL8180841 | 0.61 | HTR1F (0.44) | HTR6SMN1; SMN2MAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |