Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 12/20 | 0.41 |
| ▸ | JUN | P05412 | 7/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.41 |
| ▸ | RELA | Q04206 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATF1 | P18846 | 6/20 | 0.36 |
| ▸ | FOS | P01100 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 4/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415725 | 0.86 | KEAP1 (0.44) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL26150387 | 0.84 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL28874828 | 0.80 | MAPT (0.44) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL30574458 | 0.77 | NFKB1 (0.58) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL131646 | 0.77 | NFKB1 (0.58) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL31469871 | 0.75 | NFKB1 (0.46) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL429969 | 0.75 | NFKB1 (0.46) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL16742964 | 0.72 | PTGDR2 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL10585289 | 0.72 | ALDH1A1 (0.38) | NFKB1JUNNFKB2RELAALDH1A1 | |
| SCHEMBL79014 | 0.71 | NFKB1 (0.60) | NFKB1JUNNFKB2RELAATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260132127-A1 | NOVEL SPIRO COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2026-05-14 | — | — | US | disclosed |
| CN-118176179-A | Novel spiro compounds | 田边三菱制药株式会社 | 2024-06-11 | — | — | CN | disclosed |
| WO-2023074847-A1 | NOVEL SPIRO COMPOUND | 田辺三菱製薬株式会社 | 2023-05-04 | — | — | WO | disclosed |
| US-5852028-A | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132127-A1 | NOVEL SPIRO COMPOUND | TRHR, NR3C2, THRB | NFKB1 2906/4885JUN 4129/4885NFKB2 2381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.