Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.63 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.62 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.55 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.55 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27576378 | 0.87 | KMO (0.60) | KMOPIK3CAJMJD6SIRT2SIRT1 | |
| SCHEMBL10144997 | 0.86 | ALOX5 (0.60) | SIRT2SIRT1ALOX5MEN1KMT2A | |
| SCHEMBL3097713 | 0.86 | ALOX5 (0.60) | SIRT2SIRT1ALOX5MEN1KMT2A | |
| SCHEMBL8698788 | 0.85 | PLOD2 (0.56) | PLOD2PLOD3PLOD1ALOX5MEN1 | |
| SCHEMBL4250883 | 0.85 | KMO (0.68) | KMOPRKDCPLOD2PLOD3PLOD1 | |
| SCHEMBL4690718 | 0.84 | MEN1 (0.71) | PIK3CASIRT2SIRT1MEN1KMT2A | |
| SCHEMBL2306348 | 0.84 | ALOX5 (0.58) | ALOX5LMNAATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL4357869 | 0.83 | KMO (0.67) | KMOPRKDCPLOD2PLOD3PLOD1 | |
| SCHEMBL14881542 | 0.83 | ALOX5 (0.56) | ALOX5MEN1KMT2ALMNAATM | |
| SCHEMBL6011450 | 0.83 | ALDH1A1 (0.56) | ALOX5MEN1KMT2ALMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998047877-A1 | 2-BENZOYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HEPATIC PRODUCTION OF APOB-100 | GLAXO GROUP LIMITED (GB) | 1998-10-29 | — | — | WO | disclosed |
| US-5281720-A | Antiasthmatics, antiallergens, antiinflammatory agents and cytoprotective agents | MERCK FROSST CANADA, INC. | 1994-01-25 | — | — | US | disclosed |
| US-5227399-A | Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1993-07-13 | — | — | US | disclosed |
| EP-0501579-A1 | Naphthalene lactones as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |
| EP-0501578-A1 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1992-09-02 | — | — | EP | disclosed |