Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.37 |
| ▸ | TUBB | P07437 | 3/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8701429 | 0.80 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HCRTR1HCRTR2GAA | |
| Guanidine SCHEMBL8700578 | 0.80 | PDE4A (0.43) | ALDH1A1SMN1; SMN2HCRTR1GAAKDM4E | |
| SCHEMBL7830164 | 0.79 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2GAATUBB4ATUBB | |
| Guanidine SCHEMBL8705526 | 0.78 | AOC2 (0.49) | ALDH1A1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8705142 | 0.77 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2GAAMRGPRX1TUBB4A | |
| SCHEMBL7815979 | 0.76 | SLC9A1 (0.47) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7815984 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HCRTR1HCRTR2GAA | |
| SCHEMBL5323825 | 0.75 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2TUBB4ATUBBTUBA3C | |
| SCHEMBL8701432 | 0.74 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2HCRTR1HCRTR2GAA | |
| SCHEMBL7826071 | 0.74 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5824691-A | CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-20 | — | — | US | disclosed |