SCHEMBL8701429

SCHEMBL8701429

COc1ccc(-n2cccc2)cc1C(=O)NC(=N)N.CS(=O)(=O)O

nearest known ligand 0.45

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GHSR known ✓ Q92847 1/20 0.38
TUBB4A known ✓ P04350 1/20 0.36
TUBB known ✓ P07437 1/20 0.36
TUBA3C known ✓ P0DPH7 1/20 0.36
TUBA1B known ✓ P68363 1/20 0.36
TUBA4A known ✓ P68366 1/20 0.36
TUBB4B known ✓ P68371 1/20 0.36
TUBB3 known ✓ Q13509 1/20 0.36
TUBB2A known ✓ Q13885 1/20 0.36
TUBB8 known ✓ Q3ZCM7 1/20 0.36
TUBA3E known ✓ Q6PEY2 1/20 0.36
TUBA1A known ✓ Q71U36 1/20 0.36
TUBA1C known ✓ Q9BQE3 1/20 0.36
TUBB6 known ✓ Q9BUF5 1/20 0.36
TUBB2B known ✓ Q9BVA1 1/20 0.36
TUBB1 known ✓ Q9H4B7 1/20 0.36
ALDH1A1 P00352 5/20 0.45
SMN1; SMN2 Q16637 4/20 0.45
L3MBTL1 Q9Y468 2/20 0.40
MRGPRX1 Q96LB2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8705142 0.95 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2L3MBTL1MRGPRX1KMT2A
SCHEMBL7815979 0.80 SLC9A1 (0.47) ALDH1A1SMN1; SMN2
Guanidine SCHEMBL8701424 0.80 ALDH1A1 (0.41) ALDH1A1SMN1; SMN2L3MBTL1MRGPRX1KMT2A
SCHEMBL8700581 0.79 ALDH1A1 (0.45) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL8701432 0.78 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2L3MBTL1MRGPRX1KMT2A
SCHEMBL8701419 0.77 ALDH1A1 (0.48) ALDH1A1L3MBTL1GAAMAPTMAPK1
SCHEMBL8705529 0.77 AOC2 (0.59) ALDH1A1L3MBTL1KMT2AGAATDP1
SCHEMBL7830164 0.76 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL7815984 0.74 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2L3MBTL1KMT2AGAA
SCHEMBL5323825 0.74 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2TDP1MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5824691-A CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-10-20 US disclosed