Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | AGER | Q15109 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | GSTA1 | P08263 | 2/20 | 0.49 |
| ▸ | LIG1 | P18858 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707490 | 0.86 | RORB (0.50) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL27699633 | 0.86 | FTO (0.55) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL8654976 | 0.81 | FTO (0.45) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL8709623 | 0.81 | NPC1 (0.52) | KDM4EALDH1A1MAPTTSHRLMNA | |
| SCHEMBL8712176 | 0.81 | GSTA1 (0.63) | KDM4EALDH1A1MAPTALOX15NPSR1 | |
| SCHEMBL8651464 | 0.80 | HDAC1 (0.47) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL22406366 | 0.80 | LIG1 (0.52) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL8709808 | 0.80 | CSNK2A1 (0.50) | KDM4EALDH1A1MAPTALOX15L3MBTL1 | |
| SCHEMBL8714018 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1MAPTTSHRCYP3A4 | |
| SCHEMBL30118935 | 0.77 | KMT2A (0.58) | KDM4EALDH1A1MAPTTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |