Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712176 | 0.80 | GSTA1 (0.63) | KDM4ERAB9AGSTA1EGLN2FTO | |
| SCHEMBL8709808 | 0.79 | CSNK2A1 (0.50) | KDM4ERAB9AGSTA1EGLN2FTO | |
| SCHEMBL8654976 | 0.78 | FTO (0.45) | KDM4EGSTA1EGLN2FTOALDH1A1 | |
| SCHEMBL8709073 | 0.77 | KDM4E (0.50) | KDM4EGSTA1EGLN2FTOALDH1A1 | |
| SCHEMBL8716457 | 0.76 | CYP1A2 (0.53) | KDM4ERAB9AGSTA1ALDH1A1NPSR1 | |
| SCHEMBL8711999 | 0.75 | TRPA1 (0.42) | KDM4ERAB9AGSTA1EGLN2FTO | |
| SCHEMBL8709049 | 0.75 | MAPT (0.53) | KDM4ERAB9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8772949 | 0.75 | TLR7 (0.56) | RAB9APTGS2GSTA1ALDH1A1MEN1 | |
| SCHEMBL27699633 | 0.75 | FTO (0.55) | KDM4ERAB9AEGLN2FTOALDH1A1 | |
| SCHEMBL8709623 | 0.74 | NPC1 (0.52) | KDM4ERAB9AEGLN2FTOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |